Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GMPR (guanosine monophosphate reductase)

Identity

Other aliasGMPR 1
GMPR1
HGNC (Hugo) GMPR
LocusID (NCBI) 2766
Atlas_Id 54334
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 16238580 and ends at 16295549 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ERG (21q22.2) / GMPR (6p22.3)GMPR (6p22.3) / NDUFAF6 (8q22.1)TXLNG (Xp22.2) / GMPR (6p22.3)
GMPR 6p22.3 C8orf38

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;8)(p22;q22) GMPR/NDUFAF6
t(6;21)(p22;q22) ERG/GMPR

External links

Nomenclature
HGNC (Hugo)GMPR   4376
Cards
Entrez_Gene (NCBI)GMPR  2766  guanosine monophosphate reductase
AliasesGMPR; GMPR1
GeneCards (Weizmann)GMPR
Ensembl hg19 (Hinxton)ENSG00000137198 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137198 [Gene_View]  ENSG00000137198 [Sequence]  chr6:16238580-16295549 [Contig_View]  GMPR [Vega]
ICGC DataPortalENSG00000137198
TCGA cBioPortalGMPR
AceView (NCBI)GMPR
Genatlas (Paris)GMPR
WikiGenes2766
SOURCE (Princeton)GMPR
Genetics Home Reference (NIH)GMPR
Genomic and cartography
GoldenPath hg38 (UCSC)GMPR  -     chr6:16238580-16295549 +  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GMPR  -     6p22.3   [Description]    (hg19-Feb_2009)
GoldenPathGMPR - 6p22.3 [CytoView hg19]  GMPR - 6p22.3 [CytoView hg38]
ImmunoBaseENSG00000137198
Mapping of homologs : NCBIGMPR [Mapview hg19]  GMPR [Mapview hg38]
OMIM139265   
Gene and transcription
Genbank (Entrez)BC008281
RefSeq transcript (Entrez)NM_006877
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GMPR
Cluster EST : UnigeneHs.484741 [ NCBI ]
CGAP (NCI)Hs.484741
Alternative Splicing GalleryENSG00000137198
Gene ExpressionGMPR [ NCBI-GEO ]   GMPR [ EBI - ARRAY_EXPRESS ]   GMPR [ SEEK ]   GMPR [ MEM ]
Gene Expression Viewer (FireBrowse)GMPR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2766
GTEX Portal (Tissue expression)GMPR
Human Protein AtlasENSG00000137198-GMPR [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36959   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36959  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36959
Splice isoforms : SwissVarP36959
Catalytic activity : Enzyme1.7.1.7 [ Enzyme-Expasy ]   1.7.1.71.7.1.7 [ IntEnz-EBI ]   1.7.1.7 [ BRENDA ]   1.7.1.7 [ KEGG ]   
PhosPhoSitePlusP36959
Domaine pattern : Prosite (Expaxy)IMP_DH_GMP_RED (PS00487)   
Domains : Interpro (EBI)Aldolase_TIM    GMPR    IMP_DH/GMP_Rdtase_CS    IMP_DH_GMPRt   
Domain families : Pfam (Sanger)IMPDH (PF00478)   
Domain families : Pfam (NCBI)pfam00478   
Conserved Domain (NCBI)GMPR
DMDM Disease mutations2766
Blocks (Seattle)GMPR
PDB (RSDB)2BLE    2BWG   
PDB Europe2BLE    2BWG   
PDB (PDBSum)2BLE    2BWG   
PDB (IMB)2BLE    2BWG   
Structural Biology KnowledgeBase2BLE    2BWG   
SCOP (Structural Classification of Proteins)2BLE    2BWG   
CATH (Classification of proteins structures)2BLE    2BWG   
SuperfamilyP36959
Human Protein Atlas [tissue]ENSG00000137198-GMPR [tissue]
Peptide AtlasP36959
HPRD00754
IPIIPI00304803   
Protein Interaction databases
DIP (DOE-UCLA)P36959
IntAct (EBI)P36959
FunCoupENSG00000137198
BioGRIDGMPR
STRING (EMBL)GMPR
ZODIACGMPR
Ontologies - Pathways
QuickGOP36959
Ontology : AmiGOGMP reductase activity  cytosol  purine nucleobase metabolic process  response to cold  purine ribonucleotide interconversion  purine-containing compound salvage  metal ion binding  oxidation-reduction process  GMP reductase complex  
Ontology : EGO-EBIGMP reductase activity  cytosol  purine nucleobase metabolic process  response to cold  purine ribonucleotide interconversion  purine-containing compound salvage  metal ion binding  oxidation-reduction process  GMP reductase complex  
Pathways : KEGGPurine metabolism   
NDEx NetworkGMPR
Atlas of Cancer Signalling NetworkGMPR
Wikipedia pathwaysGMPR
Orthology - Evolution
OrthoDB2766
GeneTree (enSembl)ENSG00000137198
Phylogenetic Trees/Animal Genes : TreeFamGMPR
HOGENOMP36959
Homologs : HomoloGeneGMPR
Homology/Alignments : Family Browser (UCSC)GMPR
Gene fusions - Rearrangements
Fusion : MitelmanERG/GMPR [21q22.2/6p22.3]  [t(6;21)(p22;q22)]  
Fusion : MitelmanGMPR/NDUFAF6 [6p22.3/8q22.1]  [t(6;8)(p22;q22)]  
Fusion PortalGMPR 6p22.3 C8orf38 BRCA
Fusion : QuiverGMPR
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGMPR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GMPR
dbVarGMPR
ClinVarGMPR
1000_GenomesGMPR 
Exome Variant ServerGMPR
ExAC (Exome Aggregation Consortium)ENSG00000137198
GNOMAD BrowserENSG00000137198
Varsome BrowserGMPR
Genetic variants : HAPMAP2766
Genomic Variants (DGV)GMPR [DGVbeta]
DECIPHERGMPR [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGMPR 
Mutations
ICGC Data PortalGMPR 
TCGA Data PortalGMPR 
Broad Tumor PortalGMPR
OASIS PortalGMPR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGMPR  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGMPR
Mutations and Diseases : HGMDGMPR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GMPR
DgiDB (Drug Gene Interaction Database)GMPR
DoCM (Curated mutations)GMPR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GMPR (select a term)
intoGenGMPR
Cancer3DGMPR(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139265   
Orphanet
DisGeNETGMPR
MedgenGMPR
Genetic Testing Registry GMPR
NextProtP36959 [Medical]
TSGene2766
GENETestsGMPR
Target ValidationGMPR
Huge Navigator GMPR [HugePedia]
snp3D : Map Gene to Disease2766
BioCentury BCIQGMPR
ClinGenGMPR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2766
Chemical/Pharm GKB GenePA28761
Clinical trialGMPR
Miscellaneous
canSAR (ICR)GMPR (select the gene name)
DataMed IndexGMPR
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGMPR
EVEXGMPR
GoPubMedGMPR
iHOPGMPR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:45:06 CET 2019
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