GMPR2 (guanosine monophosphate reductase 2)

2007-02-01 Affiliation

Identity

HGNC

GMPR2

LOCATION

14q12

LOCUSID

51292

ALIAS

GMPR

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51292
MIM: 610781
HGNC: 4377
Ensembl: ENSG00000100938

Variants:

dbSNP: 51292
ClinVar: 51292
TCGA: ENSG00000100938
COSMIC: GMPR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000100938	ENST00000348719	F8WAN9
ENSG00000100938	ENST00000355299	Q9P2T1
ENSG00000100938	ENST00000399440	Q9P2T1
ENSG00000100938	ENST00000420554	Q9P2T1
ENSG00000100938	ENST00000456667	Q9P2T1
ENSG00000100938	ENST00000557854	H0YNJ6
ENSG00000100938	ENST00000558279	H0YL68
ENSG00000100938	ENST00000558483	H0YLB8
ENSG00000100938	ENST00000558748	H0YK71
ENSG00000100938	ENST00000558760	H0YKK3
ENSG00000100938	ENST00000558788	H0YMW6
ENSG00000100938	ENST00000558865	H0YNS9
ENSG00000100938	ENST00000558932	H0YN22
ENSG00000100938	ENST00000559102	H0YN74
ENSG00000100938	ENST00000559104	H0YLV5
ENSG00000100938	ENST00000559287	H0YMG3
ENSG00000100938	ENST00000559409	H0YMV5
ENSG00000100938	ENST00000559479	H0YK13
ENSG00000100938	ENST00000559836	Q9P2T1
ENSG00000100938	ENST00000559910	H0YMB3
ENSG00000100938	ENST00000559943	H0YKE1
ENSG00000100938	ENST00000560139	H0YMR9
ENSG00000100938	ENST00000561035	H0YNH0
ENSG00000100938	ENST00000561038	A0A0B4J281
ENSG00000100938	ENST00000561130	A0A0B4J281
ENSG00000100938	ENST00000620807	A0A087WWM4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Purine metabolism	KEGG	ko00230
Purine metabolism	KEGG	hsa00230
Metabolism	REACTOME	R-HSA-1430728
Metabolism of nucleotides	REACTOME	R-HSA-15869
Purine metabolism	REACTOME	R-HSA-73847
Purine salvage	REACTOME	R-HSA-74217

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
22037469	2011	Cofactor mobility determines reaction outcome in the IMPDH and GMPR (β-α)8 barrel enzymes.	11
23208589	2013	Lack of expression of the proteins GMPR2 and PPARα are associated with the basal phenotype and patient outcome in breast cancer.	7
12009299	2002	NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties.	6
21048031	2011	Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.	5
12669231	2003	Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells.	4

Citation

Dessen P

GMPR2 (guanosine monophosphate reductase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45715/gmpr2