GNAI2 (G protein subunit alpha i2)

2003-02-01 Affiliation

Identity

HGNC

GNAI2

LOCATION

3p21.31

LOCUSID

2771

ALIAS

GIP,GNAI2B,H_LUCA15.1,H_LUCA16.1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2771
MIM: 139360
HGNC: 4385
Ensembl: ENSG00000114353

Variants:

dbSNP: 2771
ClinVar: 2771
TCGA: ENSG00000114353
COSMIC: GNAI2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000114353	ENST00000266027	P04899
ENSG00000114353	ENST00000313601	P04899
ENSG00000114353	ENST00000422163	P04899
ENSG00000114353	ENST00000440628	P04899
ENSG00000114353	ENST00000441156	F8WE78
ENSG00000114353	ENST00000446079	F8WBG4
ENSG00000114353	ENST00000451956	P04899

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Gap junction	KEGG	ko04540
Leukocyte transendothelial migration	KEGG	ko04670
Long-term depression	KEGG	ko04730
Progesterone-mediated oocyte maturation	KEGG	ko04914
Melanogenesis	KEGG	ko04916
Axon guidance	KEGG	hsa04360
Gap junction	KEGG	hsa04540
Leukocyte transendothelial migration	KEGG	hsa04670
Long-term depression	KEGG	hsa04730
Melanogenesis	KEGG	hsa04916
Parkinson's disease	KEGG	hsa05012
Pathways in cancer	KEGG	hsa05200
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Progesterone-mediated oocyte maturation	KEGG	hsa04914
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Gastric acid secretion	KEGG	ko04971
Gastric acid secretion	KEGG	hsa04971
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Cholinergic synapse	KEGG	hsa04725
Pertussis	KEGG	ko05133
Pertussis	KEGG	hsa05133
GABAergic synapse	KEGG	ko04727
GABAergic synapse	KEGG	hsa04727
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Serotonergic synapse	KEGG	hsa04726
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
Estrogen signaling pathway	KEGG	hsa04915
Estrogen signaling pathway	KEGG	ko04915
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Adrenergic signaling in cardiomyocytes	KEGG	hsa04261
Adrenergic signaling in cardiomyocytes	KEGG	ko04261
Platelet activation	KEGG	hsa04611
Oxytocin signaling pathway	KEGG	hsa04921
Oxytocin signaling pathway	KEGG	ko04921
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
cAMP signaling	KEGG	hsa_M00695
cAMP signaling	KEGG	M00695
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Regulation of lipolysis in adipocytes	KEGG	hsa04923
Renin secretion	KEGG	hsa04924
Renin secretion	KEGG	ko04924
Metabolism of proteins	REACTOME	R-HSA-392499
Protein folding	REACTOME	R-HSA-391251
Chaperonin-mediated protein folding	REACTOME	R-HSA-390466
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
GABA receptor activation	REACTOME	R-HSA-977443
GABA B receptor activation	REACTOME	R-HSA-977444
Activation of GABAB receptors	REACTOME	R-HSA-991365
Inhibition of adenylate cyclase pathway	REACTOME	R-HSA-997269
Adenylate cyclase inhibitory pathway	REACTOME	R-HSA-170670
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Signal amplification	REACTOME	R-HSA-392518
ADP signalling through P2Y purinoceptor 12	REACTOME	R-HSA-392170
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (z) signalling events	REACTOME	R-HSA-418597
Opioid Signalling	REACTOME	R-HSA-111885
G-protein activation	REACTOME	R-HSA-202040
G-protein mediated events	REACTOME	R-HSA-112040
PLC beta mediated events	REACTOME	R-HSA-112043
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Adrenaline,noradrenaline inhibits insulin secretion	REACTOME	R-HSA-400042
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	REACTOME	R-HSA-6814122
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA134971947	P2RY12	Gene	Pathway	associated	20938371
PA164741137	ADCY3	Gene	Pathway	associated	20938371
PA192	HTR1A	Gene	Pathway	associated	19741567
PA24560	ADCY1	Gene	Pathway	associated	19741567
PA24561	ADCY2	Gene	Pathway	associated	19741567
PA24562	ADCY4	Gene	Pathway	associated
PA24563	ADCY5	Gene	Pathway	associated
PA27	ADCY6	Gene	Pathway	associated
PA28	ADCY7	Gene	Pathway	associated
PA29	ADCY8	Gene	Pathway	associated
PA29549	HTR1B	Gene	Pathway	associated	19741567
PA29550	HTR1D	Gene	Pathway	associated	19741567
PA29552	HTR1E	Gene	Pathway	associated	19741567
PA29553	HTR1F	Gene	Pathway	associated	19741567
PA30	ADCY9	Gene	Pathway	associated
PA34361	RGS1	Gene	Pathway	associated
PA39	ADRB2	Gene	Pathway	associated

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19542234	2009	Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2.	78
29925945	2018	Structure of the adenosine-bound human adenosine A<sub>1</sub> receptor-G<sub>i</sub> complex.	60
21079996	2011	Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma.	31
22333621	2012	Guanine nucleotide-binding protein Gαi2: a new partner of claudin-5 that regulates tight junction integrity in human brain endothelial cells.	25
25078664	2015	Requirement of Gαi1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3K-AKT-mTORC1 activation.	24
24298018	2014	Gαi2 signaling is required for skeletal muscle growth, regeneration, and satellite cell proliferation and differentiation.	18
15640523	2005	Transcriptional activation of the human Galphai2 gene promoter through nuclear factor-kappaB and antioxidant response elements.	14
27811362	2016	MicroRNA-222-3p/GNAI2/AKT axis inhibits epithelial ovarian cancer cell growth and associates with good overall survival.	14
18854172	2008	The specific activation of TRPC4 by Gi protein subtype.	13

Citation

Dessen P

GNAI2 (G protein subunit alpha i2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40726/gnai2