GNAI3 (G protein subunit alpha i3)

2006-10-01  

Identity

HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
87U6,ARCND1
FUSION GENES

Other Information

Locus ID:

NCBI: 2773
MIM: 139370
HGNC: 4387
Ensembl: ENSG00000065135

Variants:

dbSNP: 2773
ClinVar: 2773
TCGA: ENSG00000065135
COSMIC: GNAI3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065135ENST00000369851P08754

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Gap junctionKEGGko04540
Leukocyte transendothelial migrationKEGGko04670
Long-term depressionKEGGko04730
Progesterone-mediated oocyte maturationKEGGko04914
MelanogenesisKEGGko04916
Axon guidanceKEGGhsa04360
Gap junctionKEGGhsa04540
Leukocyte transendothelial migrationKEGGhsa04670
Long-term depressionKEGGhsa04730
MelanogenesisKEGGhsa04916
Parkinson's diseaseKEGGhsa05012
Pathways in cancerKEGGhsa05200
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
Progesterone-mediated oocyte maturationKEGGhsa04914
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
Gastric acid secretionKEGGko04971
Gastric acid secretionKEGGhsa04971
ToxoplasmosisKEGGko05145
ToxoplasmosisKEGGhsa05145
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Cholinergic synapseKEGGhsa04725
PertussisKEGGko05133
PertussisKEGGhsa05133
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Serotonergic synapseKEGGhsa04726
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Platelet activationKEGGhsa04611
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
cAMP signalingKEGGhsa_M00695
cAMP signalingKEGGM00695
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Regulation of lipolysis in adipocytesKEGGhsa04923
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
GABA receptor activationREACTOMER-HSA-977443
GABA B receptor activationREACTOMER-HSA-977444
Activation of GABAB receptorsREACTOMER-HSA-991365
Inhibition of adenylate cyclase pathwayREACTOMER-HSA-997269
Adenylate cyclase inhibitory pathwayREACTOMER-HSA-170670
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Signal amplificationREACTOMER-HSA-392518
ADP signalling through P2Y purinoceptor 12REACTOMER-HSA-392170
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597
Opioid SignallingREACTOMER-HSA-111885
G-protein activationREACTOMER-HSA-202040
G-protein mediated eventsREACTOMER-HSA-112040
PLC beta mediated eventsREACTOMER-HSA-112043
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122
Apelin signaling pathwayKEGGhsa04371

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA134971947P2RY12GenePathwayassociated20938371
PA164741137ADCY3GenePathwayassociated20938371
PA192HTR1AGenePathwayassociated19741567
PA24560ADCY1GenePathwayassociated19741567
PA24561ADCY2GenePathwayassociated19741567
PA24562ADCY4GenePathwayassociated
PA24563ADCY5GenePathwayassociated
PA27ADCY6GenePathwayassociated
PA28ADCY7GenePathwayassociated
PA29ADCY8GenePathwayassociated
PA29549HTR1BGenePathwayassociated19741567
PA29550HTR1DGenePathwayassociated19741567
PA29552HTR1EGenePathwayassociated19741567
PA29553HTR1FGenePathwayassociated19741567
PA30ADCY9GenePathwayassociated
PA34361RGS1GenePathwayassociated
PA39ADRB2GenePathwayassociated

References

Pubmed IDYearTitleCitations
186631452008Activation of Galphai3 triggers cell migration via regulation of GIV.79
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
212093162011A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals.55
251876472014Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.32
225600912012A human homeotic transformation resulting from mutations in PLCB4 and GNAI3 causes auriculocondylar syndrome.28
233896352013Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells.24
250786642015Requirement of Gαi1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3K-AKT-mTORC1 activation.24
263916622015Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin.23
128266072003Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP.22
206078002010TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation.20

Citation

Dessen P

GNAI3 (G protein subunit alpha i3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43277/gnai3