Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GNAO1 (G protein subunit alpha o1)

Identity

Alias_namesguanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Alias_symbol (synonym)G-ALPHA-o
Other aliasEIEE17
GNAO
HLA-DQB1
NEDIM
HGNC (Hugo) GNAO1
LocusID (NCBI) 2775
Atlas_Id 43279
Location 16q13  [Link to chromosome band 16q13]
Location_base_pair Starts at 56191489 and ends at 56348199 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBRSL1 (12q24.33) / GNAO1 (16q12.2)GNAO1 (16q12.2) / FAM81A (15q22.2)GNAO1 (16q12.2) / GNAO1 (16q12.2)
HGS (17q25.3) / GNAO1 (16q12.2)NUP93 (16q13) / GNAO1 (16q12.2)TBC1D5 (3p24.3) / GNAO1 (16q12.2)
TOX3 (16q12.1) / GNAO1 (16q12.2)ZNF711 (Xq21.1) / GNAO1 (16q12.2)HGS 17q25.3 / GNAO1 16q12.2
NUP93 16q13 / GNAO1 16q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  TOX3/GNAO1 (16q12)
t(16;17)(q12;q25) HGS/GNAO1

External links

Nomenclature
HGNC (Hugo)GNAO1   4389
Cards
Entrez_Gene (NCBI)GNAO1  2775  G protein subunit alpha o1
AliasesEIEE17; G-ALPHA-o; GNAO; HLA-DQB1; 
NEDIM
GeneCards (Weizmann)GNAO1
Ensembl hg19 (Hinxton)ENSG00000087258 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000087258 [Gene_View]  ENSG00000087258 [Sequence]  chr16:56191489-56348199 [Contig_View]  GNAO1 [Vega]
ICGC DataPortalENSG00000087258
TCGA cBioPortalGNAO1
AceView (NCBI)GNAO1
Genatlas (Paris)GNAO1
WikiGenes2775
SOURCE (Princeton)GNAO1
Genetics Home Reference (NIH)GNAO1
Genomic and cartography
GoldenPath hg38 (UCSC)GNAO1  -     chr16:56191489-56348199 +  16q13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNAO1  -     16q13   [Description]    (hg19-Feb_2009)
GoldenPathGNAO1 - 16q13 [CytoView hg19]  GNAO1 - 16q13 [CytoView hg38]
Genome Data Viewer NCBIGNAO1 [Mapview hg19]  
OMIM139311   615473   617493   
Gene and transcription
Genbank (Entrez)AF493894 AF493895 AK056008 AK295680 AL512686
RefSeq transcript (Entrez)NM_020988 NM_138736
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNAO1
Alternative Splicing GalleryENSG00000087258
Gene ExpressionGNAO1 [ NCBI-GEO ]   GNAO1 [ EBI - ARRAY_EXPRESS ]   GNAO1 [ SEEK ]   GNAO1 [ MEM ]
Gene Expression Viewer (FireBrowse)GNAO1 [ Firebrowse - Broad ]
GenevisibleExpression of GNAO1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2775
GTEX Portal (Tissue expression)GNAO1
Human Protein AtlasENSG00000087258-GNAO1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09471   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09471  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09471
Splice isoforms : SwissVarP09471
PhosPhoSitePlusP09471
Domaine pattern : Prosite (Expaxy)G_ALPHA (PS51882)   
Domains : Interpro (EBI)Gprotein_alpha_I    Gprotein_alpha_su    GproteinA_insert    P-loop_NTPase   
Domain families : Pfam (Sanger)G-alpha (PF00503)   
Domain families : Pfam (NCBI)pfam00503   
Domain families : Smart (EMBL)G_alpha (SM00275)  
Conserved Domain (NCBI)GNAO1
DMDM Disease mutations2775
PDB (RSDB)6FUF    6G79    6OIK   
PDB Europe6FUF    6G79    6OIK   
PDB (PDBSum)6FUF    6G79    6OIK   
PDB (IMB)6FUF    6G79    6OIK   
Structural Biology KnowledgeBase6FUF    6G79    6OIK   
SCOP (Structural Classification of Proteins)6FUF    6G79    6OIK   
CATH (Classification of proteins structures)6FUF    6G79    6OIK   
SuperfamilyP09471
Human Protein Atlas [tissue]ENSG00000087258-GNAO1 [tissue]
Peptide AtlasP09471
HPRD00757
IPIIPI00220281   IPI00398700   
Protein Interaction databases
DIP (DOE-UCLA)P09471
IntAct (EBI)P09471
FunCoupENSG00000087258
BioGRIDGNAO1
STRING (EMBL)GNAO1
ZODIACGNAO1
Ontologies - Pathways
QuickGOP09471
Ontology : AmiGOG protein-coupled receptor binding  GTPase activity  GTP binding  heterotrimeric G-protein complex  plasma membrane  protein folding  muscle contraction  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  dopamine receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  locomotory behavior  regulation of heart contraction  dendrite  G-protein beta/gamma-subunit complex binding  G protein-coupled serotonin receptor binding  mu-type opioid receptor binding  cell body  metal ion binding  corticotropin-releasing hormone receptor 1 binding  
Ontology : EGO-EBIG protein-coupled receptor binding  GTPase activity  GTP binding  heterotrimeric G-protein complex  plasma membrane  protein folding  muscle contraction  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  dopamine receptor signaling pathway  Wnt signaling pathway, calcium modulating pathway  locomotory behavior  regulation of heart contraction  dendrite  G-protein beta/gamma-subunit complex binding  G protein-coupled serotonin receptor binding  mu-type opioid receptor binding  cell body  metal ion binding  corticotropin-releasing hormone receptor 1 binding  
Pathways : KEGGRap1 signaling pathway    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Long-term depression    Estrogen signaling pathway    Melanogenesis    Morphine addiction    Alcoholism    Chagas disease (American trypanosomiasis)    Toxoplasmosis   
NDEx NetworkGNAO1
Atlas of Cancer Signalling NetworkGNAO1
Wikipedia pathwaysGNAO1
Orthology - Evolution
OrthoDB2775
GeneTree (enSembl)ENSG00000087258
Phylogenetic Trees/Animal Genes : TreeFamGNAO1
HOGENOMP09471
Homologs : HomoloGeneGNAO1
Homology/Alignments : Family Browser (UCSC)GNAO1
Gene fusions - Rearrangements
Fusion : MitelmanHGS/GNAO1 [17q25.3/16q12.2]  
Fusion : MitelmanNUP93/GNAO1 [16q13/16q12.2]  
Fusion : MitelmanTOX3/GNAO1 [16q12.1/16q12.2]  
Fusion PortalHGS 17q25.3 GNAO1 16q12.2 LUSC
Fusion PortalNUP93 16q13 GNAO1 16q12.2 LGG
Fusion : QuiverGNAO1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNAO1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNAO1
dbVarGNAO1
ClinVarGNAO1
1000_GenomesGNAO1 
Exome Variant ServerGNAO1
GNOMAD BrowserENSG00000087258
Varsome BrowserGNAO1
Genetic variants : HAPMAP2775
Genomic Variants (DGV)GNAO1 [DGVbeta]
DECIPHERGNAO1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNAO1 
Mutations
ICGC Data PortalGNAO1 
TCGA Data PortalGNAO1 
Broad Tumor PortalGNAO1
OASIS PortalGNAO1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNAO1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGNAO1
Mutations and Diseases : HGMDGNAO1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect GNAO1
DgiDB (Drug Gene Interaction Database)GNAO1
DoCM (Curated mutations)GNAO1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNAO1 (select a term)
intoGenGNAO1
Cancer3DGNAO1 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139311    615473    617493   
Orphanet889   
DisGeNETGNAO1
MedgenGNAO1
Genetic Testing Registry GNAO1
NextProtP09471 [Medical]
TSGene2775
GENETestsGNAO1
Open Targets GeneticsENSG00000087258  [validation]
snp3D : Map Gene to Disease2775
BioCentury BCIQGNAO1
ClinGenGNAO1
Clinical trials, drugs, therapy
Protein Interactions : CTD2775
Pharm GKB GenePA28771
Clinical trialGNAO1
Miscellaneous
canSAR (ICR)GNAO1 (select the gene name)
HarmonizomeGNAO1
DataMed IndexGNAO1
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNAO1
EVEXGNAO1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 11 19:50:33 CEST 2020
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.