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GNAS (GNAS complex locus)

Identity

Other namesAHO
C20orf45
GNAS1
GPSA
GSA
GSP
MGC33735
NESP
PHP1A
PHP1B
POH
HGNC (Hugo) GNAS
Location 20q13.32
Location_base_pair Starts at 56899821 and ends at 56919645 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GNAS   4392
Entrez_Gene (NCBI)GNAS  2778  GNAS complex locus
Cards
GeneCards (Weizmann)GNAS
Ensembl (Hinxton)ENSG00000087460 [Gene_View]  GNAS [Vega]
AceView (NCBI)GNAS
Genatlas (Paris)GNAS
euGene (Indiana)2778
SOURCE (Stanford)NM_000516 NM_001077488 NM_001077489 NM_001077490 NM_016592 NM_080425 NM_080426
Gene Expression (Array Express) ENSG00000087460
Genomic and cartography
GoldenPath (UCSC)GNAS  -  20q13.32   chr20:56899821-56919645 +  20q13.32   [Description]    (hg18-March_2006)
EnsemblGNAS - 20q13.32 [CytoView]
Mapping of homologs : NCBIGNAS [Mapview]
OMIM102200   103580   139320   166350   174800   219090   603233   612463   
Gene and transcription
Gene : Genbank (Entrez)AF064092 AF088184 AF088185 AF105253 AF493897
Reference sequence (RefSeq transcript) :SRSNM_000516 NM_001077488 NM_001077489 NM_001077490 NM_016592 NM_080425 NM_080426
Reference transcript : EntrezNM_000516 NM_001077488 NM_001077489 NM_001077490 NM_016592 NM_080425 NM_080426
RefSeq genomic : SRSAC_000063 AC_000152 NC_000020 NG_016194 NT_011362 NW_001838667 NW_927339
RefSeq genomic : EntrezAC_000063 AC_000152 NC_000020 NG_016194 NT_011362 NW_001838667 NW_927339
Consensus coding sequences : CCDS NCBIGNAS
Cluster EST : UnigeneHs.125898 [ SRS ] Hs.125898 [ NCBI ]
Alternative Splicing : Fast-db (Paris)18083
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ5JWF2 (SRS) Q5JWF2 (Expasy) Q5JWF2 (Uniprot)
With graphics : InterProQ5JWF2
Splice isoforms : VarSplice FASTAQ5JWF2(VarSplice FASTA)
Domains : Interpro (SRS)Gprotein_alpha_S    Gprotein_alpha_su    GproteinA_insert   
Domains : Interpro (EBI)Gprotein_alpha_S    Gprotein_alpha_su    GproteinA_insert   
Related proteins : CluSTrQ5JWF2
Domain families : Pfam SRSG-alpha (PF00503)   
Domain families : Pfam SangerG-alpha (PF00503)   
Domain families : Pfam NCBIpfam00503   
Domain families : Smart EMBLG_alpha (SM00275)  
Blocks (Seattle)Q5JWF2
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD00761
Protein Interaction databases
DIP (DOE-UCLA)Q5JWF2
IntAct (EBI)Q5JWF2
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIGNAS
SNP : GeneSNP UtahGNAS
SNP : HGBaseGNAS
Genetic variants : HAPMAPGNAS
Cancer Gene: CensusGNAS 
Somatic Mutations in Cancer : COSMICGNAS 
Mutations and Diseases : HGMDGNAS
Hereditary diseases : OMIM102200    103580    139320    166350    174800    219090    603233    612463   
Hereditary diseases : GENETests102200    103580    139320    166350    174800    219090    603233    612463   
Diseases : Genetic AssociationGNAS
General knowledge
Homologs : HomoloGeneGNAS
Homology/Alignments : Family Browser UCSCGNAS
Phylogenetic Trees/Animal Genes : TreeFamGNAS
Chemical/Protein Interactions : CTD2778
Keywords Ontology : AmiGOnucleotide binding  ruffle  endochondral ossification  molecular_function  GTPase activity  signal transducer activity  protein binding  GTP binding  extracellular region  membrane fraction  cytoplasm  heterotrimeric G-protein complex  plasma membrane  plasma membrane  plasma membrane  energy reserve metabolic process  signal transduction  G-protein coupled receptor protein signaling pathway  G-protein coupled receptor protein signaling pathway  activation of adenylate cyclase activity  activation of adenylate cyclase activity by dopamine receptor signaling pathway  female pregnancy  sensory perception of smell  protein secretion  hormone-mediated signaling pathway  post-embryonic development  guanyl nucleotide binding  extrinsic to membrane  intrinsic to membrane  trans-Golgi network membrane  embryonic hindlimb morphogenesis  post-embryonic body morphogenesis  response to drug  identical protein binding  positive regulation of osteoblast differentiation  positive regulation of osteoclast differentiation  intracellular transport  embryonic cranial skeleton morphogenesis  cartilage development  
Keywords Ontology : EGO-EBInucleotide binding  ruffle  endochondral ossification  molecular_function  GTPase activity  signal transducer activity  protein binding  GTP binding  extracellular region  membrane fraction  cytoplasm  heterotrimeric G-protein complex  plasma membrane  plasma membrane  plasma membrane  energy reserve metabolic process  signal transduction  G-protein coupled receptor protein signaling pathway  G-protein coupled receptor protein signaling pathway  activation of adenylate cyclase activity  activation of adenylate cyclase activity by dopamine receptor signaling pathway  female pregnancy  sensory perception of smell  protein secretion  hormone-mediated signaling pathway  post-embryonic development  guanyl nucleotide binding  extrinsic to membrane  intrinsic to membrane  trans-Golgi network membrane  embryonic hindlimb morphogenesis  post-embryonic body morphogenesis  response to drug  identical protein binding  positive regulation of osteoblast differentiation  positive regulation of osteoclast differentiation  intracellular transport  embryonic cranial skeleton morphogenesis  cartilage development  
Pathways : BIOCARTACCR3 signaling in Eosinophils [Genes]    Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor [Genes]    Attenuation of GPCR Signaling [Genes]    Roles of ?-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling [Genes]    ?-arrestins in GPCR Desensitization [Genes]    Role of ?-arrestins in the activation and targeting of MAP kinases [Genes]    Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway [Genes]    ChREBP regulation by carbohydrates and cAMP [Genes]    Transcription factor CREB and its extracellular signals [Genes]    Regulation of Spermatogenesis by CREM [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Corticosteroids and cardioprotection [Genes]    Signaling Pathway from G-Protein Families [Genes]    Activation of cAMP-dependent protein kinase, PKA [Genes]    How Progesterone Initiates the Oocyte Maturation [Genes]    Phospholipase C-epsilon pathway [Genes]    Ion Channels and Their Functional Role in Vascular Endothelium [Genes]   
Pathways : KEGGCalcium signaling pathwayGap junctionLong-term depressionTaste transductionGnRH signaling pathway
Other databases
Probes
Probes : ImagenesGNAS Related clones (RZPD - Berlin)
Literature
PubMed227 Pubmed reference(s) in Entrez
PubGeneGNAS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:34:59 CET 2010
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