GNAT3 (G protein subunit alpha transducin 3)

2014-11-01  

Identity

HGNC
LOCATION
7q21.11
LOCUSID
ALIAS
GDCA

Other Information

Locus ID:

NCBI: 346562
MIM: 139395
HGNC: 22800
Ensembl: ENSG00000214415

Variants:

dbSNP: 346562
ClinVar: 346562
TCGA: ENSG00000214415
COSMIC: GNAT3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000214415ENST00000398291A8MTJ3

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Carbohydrate digestion and absorptionKEGGko04973
Carbohydrate digestion and absorptionKEGGhsa04973
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Peptide hormone metabolismREACTOMER-HSA-2980736
Incretin synthesis, secretion, and inactivationREACTOMER-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)REACTOMER-HSA-381771
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
GABA receptor activationREACTOMER-HSA-977443
GABA B receptor activationREACTOMER-HSA-977444
Activation of GABAB receptorsREACTOMER-HSA-991365
Inhibition of adenylate cyclase pathwayREACTOMER-HSA-997269
Adenylate cyclase inhibitory pathwayREACTOMER-HSA-170670
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Signal amplificationREACTOMER-HSA-392518
ADP signalling through P2Y purinoceptor 12REACTOMER-HSA-392170
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597
Opioid SignallingREACTOMER-HSA-111885
G-protein activationREACTOMER-HSA-202040
G-protein mediated eventsREACTOMER-HSA-112040
PLC beta mediated eventsREACTOMER-HSA-112043
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

References

Pubmed IDYearTitleCitations
213245682011The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY).57
208587772010Taste genes associated with dental caries.37
206600572010Association between common variation in genes encoding sweet taste signaling components and human sucrose perception.24
167287272006Colocalization of the alpha-subunit of gustducin with PYY and GLP-1 in L cells of human colon.0
170218312007Expression of the G-protein alpha-subunit gustducin in mammalian spermatozoa.0
224565412012Metabolic syndrome is linked to chromosome 7q21 and associated with genetic variants in CD36 and GNAT3 in Mexican Americans.0

Citation

Dessen P

GNAT3 (G protein subunit alpha transducin 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63860/gnat3