GNAZ (G protein subunit alpha z)

2006-10-01  

Identity

HGNC
LOCATION
22q11.22
LOCUSID
ALIAS
gz-alpha
FUSION GENES

Other Information

Locus ID:

NCBI: 2781
MIM: 139160
HGNC: 4395
Ensembl: ENSG00000128266

Variants:

dbSNP: 2781
ClinVar: 2781
TCGA: ENSG00000128266
COSMIC: GNAZ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128266ENST00000615612P19086

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Long-term depressionKEGGko04730
Long-term depressionKEGGhsa04730
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (z) signalling eventsREACTOMER-HSA-418597
Opioid SignallingREACTOMER-HSA-111885
G-protein activationREACTOMER-HSA-202040
G-protein mediated eventsREACTOMER-HSA-112040
PLC beta mediated eventsREACTOMER-HSA-112043
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingREACTOMER-HSA-6814122

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
345300872022Overexpressed GNAZ predicts poor outcome and promotes G0/G1 cell cycle progression in hepatocellular carcinoma.4
345300872022Overexpressed GNAZ predicts poor outcome and promotes G0/G1 cell cycle progression in hepatocellular carcinoma.4
306278182019Downregulation of genes outside the deleted region in individuals with 22q11.2 deletion syndrome.8
306278182019Downregulation of genes outside the deleted region in individuals with 22q11.2 deletion syndrome.8
204245192010Novel somatic mutations in heterotrimeric G proteins in melanoma.13
204245192010Novel somatic mutations in heterotrimeric G proteins in melanoma.13
153262212004Galphaz inhibits serum response factor-dependent transcription by inhibiting Rho signaling.3
153262212004Galphaz inhibits serum response factor-dependent transcription by inhibiting Rho signaling.3

Citation

Dessen P

GNAZ (G protein subunit alpha z)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43283/gnaz