GNB3 (G protein subunit beta 3)

2006-10-01 Affiliation

Identity

HGNC

GNB3

LOCATION

12p13.31

LOCUSID

2784

ALIAS

CSNB1H

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2784
MIM: 139130
HGNC: 4400
Ensembl: ENSG00000111664

Variants:

dbSNP: 2784
ClinVar: 2784
TCGA: ENSG00000111664
COSMIC: GNB3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000111664	ENST00000229264	P16520
ENSG00000111664	ENST00000229264	F1T0G5
ENSG00000111664	ENST00000435982	E9PCP0
ENSG00000111664	ENST00000537035	F5H0S8
ENSG00000111664	ENST00000539127	F5GZN8
ENSG00000111664	ENST00000541257	F5H8J8
ENSG00000111664	ENST00000541978	F5H100

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Taste transduction	KEGG	ko04742
Taste transduction	KEGG	hsa04742
Pathways in cancer	KEGG	hsa05200
Chemokine signaling pathway	KEGG	ko04062
Chemokine signaling pathway	KEGG	hsa04062
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Cholinergic synapse	KEGG	hsa04725
GABAergic synapse	KEGG	ko04727
GABAergic synapse	KEGG	hsa04727
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Serotonergic synapse	KEGG	hsa04726
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Morphine addiction	KEGG	hsa05032
Morphine addiction	KEGG	ko05032
Alcoholism	KEGG	hsa05034
Alcoholism	KEGG	ko05034
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
Ras signaling pathway	KEGG	hsa04014
Metabolism of proteins	REACTOME	R-HSA-392499
Protein folding	REACTOME	R-HSA-391251
Chaperonin-mediated protein folding	REACTOME	R-HSA-390466
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Incretin synthesis, secretion, and inactivation	REACTOME	R-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	REACTOME	R-HSA-381771
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Activation of Kainate Receptors upon glutamate binding	REACTOME	R-HSA-451326
Presynaptic function of Kainate receptors	REACTOME	R-HSA-500657
GABA receptor activation	REACTOME	R-HSA-977443
GABA B receptor activation	REACTOME	R-HSA-977444
Activation of GABAB receptors	REACTOME	R-HSA-991365
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	REACTOME	R-HSA-997272
Potassium Channels	REACTOME	R-HSA-1296071
Inwardly rectifying K+ channels	REACTOME	R-HSA-1296065
G protein gated Potassium channels	REACTOME	R-HSA-1296059
Activation of G protein gated Potassium channels	REACTOME	R-HSA-1296041
Hemostasis	REACTOME	R-HSA-109582
Platelet homeostasis	REACTOME	R-HSA-418346
Prostacyclin signalling through prostacyclin receptor	REACTOME	R-HSA-392851
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Signal amplification	REACTOME	R-HSA-392518
ADP signalling through P2Y purinoceptor 12	REACTOME	R-HSA-392170
ADP signalling through P2Y purinoceptor 1	REACTOME	R-HSA-418592
Thromboxane signalling through TP receptor	REACTOME	R-HSA-428930
Thrombin signalling through proteinase activated receptors (PARs)	REACTOME	R-HSA-456926
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080
Glucagon-type ligand receptors	REACTOME	R-HSA-420092
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (z) signalling events	REACTOME	R-HSA-418597
G alpha (q) signalling events	REACTOME	R-HSA-416476
G alpha (12/13) signalling events	REACTOME	R-HSA-416482
G-protein beta:gamma signalling	REACTOME	R-HSA-397795
G beta:gamma signalling through PI3Kgamma	REACTOME	R-HSA-392451
G beta:gamma signalling through PLC beta	REACTOME	R-HSA-418217
Opioid Signalling	REACTOME	R-HSA-111885
G-protein activation	REACTOME	R-HSA-202040
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Wnt	REACTOME	R-HSA-195721
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
Ca2+ pathway	REACTOME	R-HSA-4086398
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Aquaporin-mediated transport	REACTOME	R-HSA-445717
Vasopressin regulates renal water homeostasis via Aquaporins	REACTOME	R-HSA-432040
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Adrenaline,noradrenaline inhibits insulin secretion	REACTOME	R-HSA-400042
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	REACTOME	R-HSA-381676
Glucagon signaling in metabolic regulation	REACTOME	R-HSA-163359
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	REACTOME	R-HSA-6814122
Apelin signaling pathway	KEGG	hsa04371

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA128406954	Weight gain	Disease	ClinicalAnnotation	associated	PD	19193342
PA133950441	hmg coa reductase inhibitors	Chemical	ClinicalAnnotation	associated	PD	18551043
PA134971947	P2RY12	Gene	Pathway	associated		20938371
PA164712535	Beta Blocking Agents	Chemical	ClinicalAnnotation	associated		20860462
PA164713347	Thiazides, plain	Chemical	ClinicalAnnotation	associated	PD	19247266
PA164741137	ADCY3	Gene	Pathway	associated		20938371
PA166176017	hydralazine / isosorbide dinitrate	Chemical	ClinicalAnnotation	associated	PD	25306451
PA27946	F2R	Gene	Pathway	associated		20938371
PA27949	F2RL3	Gene	Pathway	associated		20938371
PA32868	P2RY1	Gene	Pathway	associated		20938371
PA33384	PLCB1	Gene	Pathway	associated		20938371
PA33385	PLCB2	Gene	Pathway	associated
PA33386	PLCB3	Gene	Pathway	associated
PA33387	PLCB4	Gene	Pathway	associated
PA33393	PLCG2	Gene	Pathway	associated		20938371
PA348	TBXA2R	Gene	Pathway	associated		20938371
PA443742	Cluster Headache	Disease	ClinicalAnnotation	associated	PD	17361120
PA443886	Diabetes Mellitus	Disease	ClinicalAnnotation	associated	PD	19247266
PA444370	Heart Failure	Disease	ClinicalAnnotation	associated	PD	25306451
PA444516	Hypercholesterolemia	Disease	ClinicalAnnotation	associated	PD	18551043
PA444606	Erectile Dysfunction	Disease	ClinicalAnnotation	associated	PD	12576843
PA444797	Liver Cirrhosis	Disease	ClinicalAnnotation	associated	PD	12844135, 20833658
PA445019	Myocardial Infarction	Disease	ClinicalAnnotation	associated	PD	18551043
PA445043	Opioid-Related Disorders	Disease	ClinicalAnnotation	associated	PD	19303909
PA445131	Obesity	Disease	ClinicalAnnotation	associated	PD	12893983
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated	PD	19193342
PA447288	Essential hypertension	Disease	ClinicalAnnotation	associated	PD	20235788
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	20826553, 23733030, 30324302
PA448499	atenolol	Chemical	ClinicalAnnotation	associated	PD	20235788
PA448682	bumetanide	Chemical	ClinicalAnnotation	associated	PD	20877298
PA449051	clonidine	Chemical	ClinicalAnnotation	associated	PD	12844135, 20833658
PA449719	furosemide	Chemical	ClinicalAnnotation	associated	PD	20877298
PA450401	methadone	Chemical	ClinicalAnnotation	associated	PD	19303909
PA450657	nortriptyline	Chemical	ClinicalAnnotation	associated	PD	20826553
PA450688	olanzapine	Chemical	ClinicalAnnotation	associated	PD	19193342
PA451333	sertraline	Chemical	ClinicalAnnotation	associated	PD	30324302
PA451344	sibutramine	Chemical	ClinicalAnnotation	associated	PD	12893983
PA451346	sildenafil	Chemical	ClinicalAnnotation	associated	PD	12576843
PA451566	sumatriptan	Chemical	ClinicalAnnotation	associated	PD	17361120
PA451605	telmisartan	Chemical	ClinicalAnnotation	associated	PD
PA451733	torasemide	Chemical	ClinicalAnnotation	associated	PD	20877298
PA452229	antidepressants	Chemical	ClinicalAnnotation	associated	PD	23733030

References

Pubmed ID	Year	Title	Citations
37997634	2024	Association of GNB3, ACE polymorphisms with POAG and NTG.	0
37997634	2024	Association of GNB3, ACE polymorphisms with POAG and NTG.	0
38126445	2023	G Protein Subunit Beta 3 (GNB3) Variant Is Associated with Biochemical Changes in Brazilian Patients with Hypertension.	1
38126445	2023	G Protein Subunit Beta 3 (GNB3) Variant Is Associated with Biochemical Changes in Brazilian Patients with Hypertension.	1
35373932	2022	Association of miRNA targetome variants in LAMC1 and GNB3 genes with colorectal cancer and obesity.	2
35489051	2022	Endothelium function biomarkers and carotid intima-media thickness changes in relation to NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphism in the essential arterial hypertension.	1
35373932	2022	Association of miRNA targetome variants in LAMC1 and GNB3 genes with colorectal cancer and obesity.	2
35489051	2022	Endothelium function biomarkers and carotid intima-media thickness changes in relation to NOS3 (rs2070744) and GNB3 (rs5443) genes polymorphism in the essential arterial hypertension.	1
33368205	2021	Meta-analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre-eclampsia.	1
33368205	2021	Meta-analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre-eclampsia.	1
31768945	2020	Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.	5
32391916	2020	Lack of association between the GNB3 rs5443, HIF1A rs11549465 polymorphisms, physiological and functional characteristics.	3
31768945	2020	Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.	5
32391916	2020	Lack of association between the GNB3 rs5443, HIF1A rs11549465 polymorphisms, physiological and functional characteristics.	3
30253706	2019	Association of SDF1β (G801A) and GNB3 (C825T) polymorphisms with the incidence and severity of coronary artery disease.	1

Citation

Dessen P

GNB3 (G protein subunit beta 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43286/gnb3

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