Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 59345
MIM: 610863
HGNC: 20731
Ensembl: ENSG00000114450
Variants:
dbSNP: 59345
ClinVar: 59345
TCGA: ENSG00000114450
COSMIC: GNB4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000114450 | ENST00000232564 | Q9HAV0 |
| ENSG00000114450 | ENST00000466899 | H7C5J5 |
| ENSG00000114450 | ENST00000468623 | Q9HAV0 |
| ENSG00000114450 | ENST00000497513 | C9JD14 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA33384 | PLCB1 | Gene | Pathway | associated | |||
| PA33385 | PLCB2 | Gene | Pathway | associated | |||
| PA33386 | PLCB3 | Gene | Pathway | associated | |||
| PA33387 | PLCB4 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38154055 | 2024 | Plasma methylated GNB4 and Riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma. | 2 |
| 38154055 | 2024 | Plasma methylated GNB4 and Riplet as a novel dual-marker panel for the detection of hepatocellular carcinoma. | 2 |
| 37016382 | 2023 | Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo-YAP1 pathway. | 5 |
| 37016382 | 2023 | Helicobacter pylori-induced aberrant demethylation and expression of GNB4 promotes gastric carcinogenesis via the Hippo-YAP1 pathway. | 5 |
| 35756485 | 2022 | Prognostic and Immunological Value of GNB4 in Gastric Cancer by Analyzing TCGA Database. | 4 |
| 35756485 | 2022 | Prognostic and Immunological Value of GNB4 in Gastric Cancer by Analyzing TCGA Database. | 4 |
| 34398348 | 2021 | High G protein subunit beta 4 protein level is correlated to poor prognosis of urothelial carcinoma. | 4 |
| 34398348 | 2021 | High G protein subunit beta 4 protein level is correlated to poor prognosis of urothelial carcinoma. | 4 |
| 32747927 | 2020 | Guanine nucleotide-binding protein subunit beta-4 promotes gastric cancer progression via activating Erk1/2. | 9 |
| 32747927 | 2020 | Guanine nucleotide-binding protein subunit beta-4 promotes gastric cancer progression via activating Erk1/2. | 9 |
| 30103729 | 2018 | A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells. | 15 |
| 30103729 | 2018 | A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells. | 15 |
| 28642160 | 2017 | A novel missense variant (Gln220Arg) of GNB4 encoding guanine nucleotide-binding protein, subunit beta-4 in a Japanese family with autosomal dominant motor and sensory neuropathy. | 5 |
| 28642160 | 2017 | A novel missense variant (Gln220Arg) of GNB4 encoding guanine nucleotide-binding protein, subunit beta-4 in a Japanese family with autosomal dominant motor and sensory neuropathy. | 5 |
| 25916507 | 2015 | Gβ4γ1 as a modulator of M3 muscarinic receptor signalling and novel roles of Gβ1 subunits in the modulation of cellular signalling. | 9 |
Citation
Dessen P
GNB4 (G protein subunit beta 4)
Atlas Genet Cytogenet Oncol Haematol. 2006-10-01
Online version: http://atlasgeneticsoncology.org/gene/43287/gnb4
