Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GNB5 (G protein subunit beta 5)

Identity

Alias (NCBI)GB5
IDDCA
LADCI
gbeta5
HGNC (Hugo) GNB5
HGNC Alias symbGB5
HGNC Alias nameGuanine nucleotide-binding protein subunit beta-5
 Transducin beta chain 5
HGNC Previous nameguanine nucleotide binding protein (G protein), beta 5
LocusID (NCBI) 10681
Atlas_Id 43288
Location 15q21.2  [Link to chromosome band 15q21]
Location_base_pair Starts at 52115100 and ends at 52191392 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GNB5 (15q21.2) / PDE6D (2q37.1)GNB5 (15q21.2) / RBM15 (1p13.3)GNB5 (15q21.2) / RGS1 (1q31.2)
NEMF (14q21.3) / GNB5 (15q21.2)SEPT6 (Xq24) / GNB5 (15q21.2)GNB5 15q21.2 / PDE6D 2q37.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)GNB5   4401
Cards
Entrez_Gene (NCBI)GNB5    G protein subunit beta 5
AliasesGB5; IDDCA; LADCI; gbeta5
GeneCards (Weizmann)GNB5
Ensembl hg19 (Hinxton)ENSG00000069966 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000069966 [Gene_View]  ENSG00000069966 [Sequence]  chr15:52115100-52191392 [Contig_View]  GNB5 [Vega]
ICGC DataPortalENSG00000069966
TCGA cBioPortalGNB5
AceView (NCBI)GNB5
Genatlas (Paris)GNB5
SOURCE (Princeton)GNB5
Genetics Home Reference (NIH)GNB5
Genomic and cartography
GoldenPath hg38 (UCSC)GNB5  -     chr15:52115100-52191392 -  15q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNB5  -     15q21.2   [Description]    (hg19-Feb_2009)
GoldenPathGNB5 - 15q21.2 [CytoView hg19]  GNB5 - 15q21.2 [CytoView hg38]
ImmunoBaseENSG00000069966
genome Data Viewer NCBIGNB5 [Mapview hg19]  
OMIM604447   617173   617182   
Gene and transcription
Genbank (Entrez)AF017656 AF300650 AF501885 AK094776 AK125702
RefSeq transcript (Entrez)NM_001379343 NM_006578 NM_016194
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNB5
Alternative Splicing GalleryENSG00000069966
Gene ExpressionGNB5 [ NCBI-GEO ]   GNB5 [ EBI - ARRAY_EXPRESS ]   GNB5 [ SEEK ]   GNB5 [ MEM ]
Gene Expression Viewer (FireBrowse)GNB5 [ Firebrowse - Broad ]
GenevisibleExpression of GNB5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10681
GTEX Portal (Tissue expression)GNB5
Human Protein AtlasENSG00000069966-GNB5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14775   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO14775  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14775
Splice isoforms : SwissVarO14775
PhosPhoSitePlusO14775
Domaine pattern : Prosite (Expaxy)WD_REPEATS_1 (PS00678)    WD_REPEATS_2 (PS50082)    WD_REPEATS_REGION (PS50294)   
Domains : Interpro (EBI)G-protein_beta_WD-40_rep    Gprotein_B    Guanine_nucleotide-bd_bsu    WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_CS    WD40_repeat_dom    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)WD40 (PF00400)   
Domain families : Pfam (NCBI)pfam00400   
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)GNB5
Blocks (Seattle)GNB5
SuperfamilyO14775
Human Protein Atlas [tissue]ENSG00000069966-GNB5 [tissue]
Peptide AtlasO14775
HPRD09191
IPIIPI00151607   IPI00745232   IPI00967497   IPI01014336   IPI00386609   
Protein Interaction databases
DIP (DOE-UCLA)O14775
IntAct (EBI)O14775
BioGRIDGNB5
STRING (EMBL)GNB5
ZODIACGNB5
Ontologies - Pathways
QuickGOO14775
Ontology : AmiGOGTPase activity  GTPase activator activity  GTPase activator activity  GTPase activator activity  protein binding  nucleus  cytoplasm  cytosol  cytosol  heterotrimeric G-protein complex  protein folding  signal transduction  G protein-coupled receptor signaling pathway  dopamine receptor signaling pathway  dopamine receptor signaling pathway  G-protein gamma-subunit binding  G-protein gamma-subunit binding  positive regulation of GTPase activity  positive regulation of GTPase activity  chaperone binding  presynapse  negative regulation of voltage-gated calcium channel activity  GTPase activator complex  
Ontology : EGO-EBIGTPase activity  GTPase activator activity  GTPase activator activity  GTPase activator activity  protein binding  nucleus  cytoplasm  cytosol  cytosol  heterotrimeric G-protein complex  protein folding  signal transduction  G protein-coupled receptor signaling pathway  dopamine receptor signaling pathway  dopamine receptor signaling pathway  G-protein gamma-subunit binding  G-protein gamma-subunit binding  positive regulation of GTPase activity  positive regulation of GTPase activity  chaperone binding  presynapse  negative regulation of voltage-gated calcium channel activity  GTPase activator complex  
Pathways : KEGGRas signaling pathway    Chemokine signaling pathway    PI3K-Akt signaling pathway    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Morphine addiction    Alcoholism   
NDEx NetworkGNB5
Atlas of Cancer Signalling NetworkGNB5
Wikipedia pathwaysGNB5
Orthology - Evolution
OrthoDB10681
GeneTree (enSembl)ENSG00000069966
Phylogenetic Trees/Animal Genes : TreeFamGNB5
HOGENOMO14775
Homologs : HomoloGeneGNB5
Homology/Alignments : Family Browser (UCSC)GNB5
Gene fusions - Rearrangements
Fusion : MitelmanGNB5/PDE6D [15q21.2/2q37.1]  
Fusion PortalGNB5 15q21.2 PDE6D 2q37.1 BRCA
Fusion : QuiverGNB5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNB5 [hg38]
dbVarGNB5
ClinVarGNB5
MonarchGNB5
1000_GenomesGNB5 
Exome Variant ServerGNB5
GNOMAD BrowserENSG00000069966
Varsome BrowserGNB5
Genomic Variants (DGV)GNB5 [DGVbeta]
DECIPHERGNB5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNB5 
Mutations
ICGC Data PortalGNB5 
TCGA Data PortalGNB5 
Broad Tumor PortalGNB5
OASIS PortalGNB5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNB5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGNB5
Mutations and Diseases : HGMDGNB5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNB5
DgiDB (Drug Gene Interaction Database)GNB5
DoCM (Curated mutations)GNB5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNB5 (select a term)
intoGenGNB5
Cancer3DGNB5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604447    617173    617182   
Orphanet
DisGeNETGNB5
MedgenGNB5
Genetic Testing Registry GNB5
NextProtO14775 [Medical]
GENETestsGNB5
Target ValidationGNB5
Huge Navigator GNB5 [HugePedia]
ClinGenGNB5
Clinical trials, drugs, therapy
MyCancerGenomeGNB5
Protein Interactions : CTD
Pharm GKB GenePA28780
PharosO14775
Clinical trialGNB5
Miscellaneous
canSAR (ICR)GNB5 (select the gene name)
HarmonizomeGNB5
DataMed IndexGNB5
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGNB5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:23:24 CET 2021

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