Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GNG12 (G protein subunit gamma 12)

Identity

Alias_namesguanine nucleotide binding protein (G protein), gamma 12
Other alias-
HGNC (Hugo) GNG12
LocusID (NCBI) 55970
Atlas_Id 43291
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 67701466 and ends at 67833472 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GNG12 (1p31.3) / DIRAS3 (1p31.3)GNG12 (1p31.3) / GNG12 (1p31.3)GNG12 1p31.3 / DIRAS3 1p31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  GNG12/DIRAS3 (1p31)

External links

Nomenclature
HGNC (Hugo)GNG12   19663
Cards
Entrez_Gene (NCBI)GNG12  55970  G protein subunit gamma 12
Aliases
GeneCards (Weizmann)GNG12
Ensembl hg19 (Hinxton)ENSG00000172380 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172380 [Gene_View]  ENSG00000172380 [Sequence]  chr1:67701466-67833472 [Contig_View]  GNG12 [Vega]
ICGC DataPortalENSG00000172380
TCGA cBioPortalGNG12
AceView (NCBI)GNG12
Genatlas (Paris)GNG12
WikiGenes55970
SOURCE (Princeton)GNG12
Genetics Home Reference (NIH)GNG12
Genomic and cartography
GoldenPath hg38 (UCSC)GNG12  -     chr1:67701466-67833472 -  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GNG12  -     1p31.3   [Description]    (hg19-Feb_2009)
GoldenPathGNG12 - 1p31.3 [CytoView hg19]  GNG12 - 1p31.3 [CytoView hg38]
ImmunoBaseENSG00000172380
Mapping of homologs : NCBIGNG12 [Mapview hg19]  GNG12 [Mapview hg38]
OMIM615405   
Gene and transcription
Genbank (Entrez)AF119663 AF123766 AF365871 AF493879 AK055914
RefSeq transcript (Entrez)NM_018841
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GNG12
Cluster EST : UnigeneHs.431101 [ NCBI ]
CGAP (NCI)Hs.431101
Alternative Splicing GalleryENSG00000172380
Gene ExpressionGNG12 [ NCBI-GEO ]   GNG12 [ EBI - ARRAY_EXPRESS ]   GNG12 [ SEEK ]   GNG12 [ MEM ]
Gene Expression Viewer (FireBrowse)GNG12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55970
GTEX Portal (Tissue expression)GNG12
Human Protein AtlasENSG00000172380-GNG12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBI6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBI6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBI6
Splice isoforms : SwissVarQ9UBI6
PhosPhoSitePlusQ9UBI6
Domaine pattern : Prosite (Expaxy)G_PROTEIN_GAMMA (PS50058)   
Domains : Interpro (EBI)G-protein_gamma-like_dom    GGL_sf    Gprotein-gamma   
Domain families : Pfam (Sanger)G-gamma (PF00631)   
Domain families : Pfam (NCBI)pfam00631   
Domain families : Smart (EMBL)GGL (SM00224)  
Conserved Domain (NCBI)GNG12
DMDM Disease mutations55970
Blocks (Seattle)GNG12
SuperfamilyQ9UBI6
Human Protein Atlas [tissue]ENSG00000172380-GNG12 [tissue]
Peptide AtlasQ9UBI6
HPRD13592
IPIIPI00221232   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBI6
IntAct (EBI)Q9UBI6
FunCoupENSG00000172380
BioGRIDGNG12
STRING (EMBL)GNG12
ZODIACGNG12
Ontologies - Pathways
QuickGOQ9UBI6
Ontology : AmiGOGTPase activity  protein binding  heterotrimeric G-protein complex  actin filament  plasma membrane  signal transduction  G protein-coupled receptor signaling pathway  cerebral cortex development  PDZ domain binding  G-protein beta/gamma-subunit complex  G-protein beta-subunit binding  response to lipopolysaccharide  phosphate ion binding  extracellular exosome  
Ontology : EGO-EBIGTPase activity  protein binding  heterotrimeric G-protein complex  actin filament  plasma membrane  signal transduction  G protein-coupled receptor signaling pathway  cerebral cortex development  PDZ domain binding  G-protein beta/gamma-subunit complex  G-protein beta-subunit binding  response to lipopolysaccharide  phosphate ion binding  extracellular exosome  
Pathways : KEGGMAPK signaling pathway    Ras signaling pathway    Chemokine signaling pathway    PI3K-Akt signaling pathway    Circadian entrainment    Retrograde endocannabinoid signaling    Glutamatergic synapse    Cholinergic synapse    Serotonergic synapse    GABAergic synapse    Dopaminergic synapse    Regulation of actin cytoskeleton    Morphine addiction    Alcoholism   
NDEx NetworkGNG12
Atlas of Cancer Signalling NetworkGNG12
Wikipedia pathwaysGNG12
Orthology - Evolution
OrthoDB55970
GeneTree (enSembl)ENSG00000172380
Phylogenetic Trees/Animal Genes : TreeFamGNG12
HOGENOMQ9UBI6
Homologs : HomoloGeneGNG12
Homology/Alignments : Family Browser (UCSC)GNG12
Gene fusions - Rearrangements
Fusion : MitelmanGNG12/DIRAS3 [1p31.3/1p31.3]  
Fusion PortalGNG12 1p31.3 DIRAS3 1p31.3 LUAD PRAD
Fusion : QuiverGNG12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGNG12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNG12
dbVarGNG12
ClinVarGNG12
1000_GenomesGNG12 
Exome Variant ServerGNG12
ExAC (Exome Aggregation Consortium)ENSG00000172380
GNOMAD BrowserENSG00000172380
Varsome BrowserGNG12
Genetic variants : HAPMAP55970
Genomic Variants (DGV)GNG12 [DGVbeta]
DECIPHERGNG12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGNG12 
Mutations
ICGC Data PortalGNG12 
TCGA Data PortalGNG12 
Broad Tumor PortalGNG12
OASIS PortalGNG12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGNG12  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGNG12
Mutations and Diseases : HGMDGNG12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GNG12
DgiDB (Drug Gene Interaction Database)GNG12
DoCM (Curated mutations)GNG12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GNG12 (select a term)
intoGenGNG12
Cancer3DGNG12(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615405   
Orphanet
DisGeNETGNG12
MedgenGNG12
Genetic Testing Registry GNG12
NextProtQ9UBI6 [Medical]
TSGene55970
GENETestsGNG12
Target ValidationGNG12
Huge Navigator GNG12 [HugePedia]
snp3D : Map Gene to Disease55970
BioCentury BCIQGNG12
ClinGenGNG12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55970
Chemical/Pharm GKB GenePA134956700
Clinical trialGNG12
Miscellaneous
canSAR (ICR)GNG12 (select the gene name)
DataMed IndexGNG12
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGNG12
EVEXGNG12
GoPubMedGNG12
iHOPGNG12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:45:11 CET 2019
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