GNRH1 (gonadotropin releasing hormone 1)

2007-02-01  

Identity

HGNC
LOCATION
8p21.2
LOCUSID
ALIAS
GNRH,GRH,LHRH,LNRH

Other Information

Locus ID:

NCBI: 2796
MIM: 152760
HGNC: 4419
Ensembl: ENSG00000147437

Variants:

dbSNP: 2796
ClinVar: 2796
TCGA: ENSG00000147437
COSMIC: GNRH1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147437ENST00000276414P01148
ENSG00000147437ENST00000421054P01148

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
GnRH signaling pathwayKEGGko04912
GnRH signaling pathwayKEGGhsa04912
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
390109032024Variety of genetic defects in GnRH and hypothalamic-pituitary signaling and development in normosmic patients with IHH.0
390109032024Variety of genetic defects in GnRH and hypothalamic-pituitary signaling and development in normosmic patients with IHH.0
372613902023New Horizons: Gonadotropin-Releasing Hormone and Cognition.4
372613902023New Horizons: Gonadotropin-Releasing Hormone and Cognition.4
349234912022GNRH1 Variants in Congenital Hypogonadotropic Hypogonadism: Single-Center Experience and Systematic Literature Review.2
364463222022History of Puberty: Normal and Precocious.2
349234912022GNRH1 Variants in Congenital Hypogonadotropic Hypogonadism: Single-Center Experience and Systematic Literature Review.2
364463222022History of Puberty: Normal and Precocious.2
336526062021Expression of Luteinizing Hormone-Releasing Hormone (LHRH) and Type-I LHRH Receptor in Transitional Cell Carcinoma Type of Human Bladder Cancer.0
339643202021The KiNG of reproduction: Kisspeptin/ nNOS interactions shaping hypothalamic GnRH release.6
341041222021Investigation of Specific Targeting of Triptorelin-Conjugated Dextran-Coated Magnetite Nanoparticles as a Targeted Probe in GnRH(+) Cancer Cells in MRI.3
336526062021Expression of Luteinizing Hormone-Releasing Hormone (LHRH) and Type-I LHRH Receptor in Transitional Cell Carcinoma Type of Human Bladder Cancer.0
339643202021The KiNG of reproduction: Kisspeptin/ nNOS interactions shaping hypothalamic GnRH release.6
341041222021Investigation of Specific Targeting of Triptorelin-Conjugated Dextran-Coated Magnetite Nanoparticles as a Targeted Probe in GnRH(+) Cancer Cells in MRI.3
283858882017Modeling and high-throughput experimental data uncover the mechanisms underlying Fshb gene sensitivity to gonadotropin-releasing hormone pulse frequency.10

Citation

Dessen P

GNRH1 (gonadotropin releasing hormone 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43708/gnrh1