GNRH2 (gonadotropin releasing hormone 2)

2007-02-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
GnRH-II,LH-RHII

Other Information

Locus ID:

NCBI: 2797
MIM: 602352
HGNC: 4420
Ensembl: ENSG00000125787

Variants:

dbSNP: 2797
ClinVar: 2797
TCGA: ENSG00000125787
COSMIC: GNRH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125787ENST00000245983O43555
ENSG00000125787ENST00000359100O43555
ENSG00000125787ENST00000380346O43555
ENSG00000125787ENST00000380347O43555

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
GnRH signaling pathwayKEGGko04912
GnRH signaling pathwayKEGGhsa04912
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378949502023EGF-Enhanced GnRH-II Regulation in Decidual Stromal Cell Motility through Twist and N-Cadherin Signaling.0
382601302023Role of gonadotropin-releasing hormone 2 and its receptor in human reproductive cancers.0
378949502023EGF-Enhanced GnRH-II Regulation in Decidual Stromal Cell Motility through Twist and N-Cadherin Signaling.0
382601302023Role of gonadotropin-releasing hormone 2 and its receptor in human reproductive cancers.0
329944242020The effects of common variants in MDM2 and GNRH2 genes on the risk and survival of osteosarcoma in Han populations from Northwest China.1
331143332020Copper(II) Binding by the Earliest Vertebrate Gonadotropin-Releasing Hormone, the Type II Isoform, Suggests an Ancient Role for the Metal.2
329944242020The effects of common variants in MDM2 and GNRH2 genes on the risk and survival of osteosarcoma in Han populations from Northwest China.1
331143332020Copper(II) Binding by the Earliest Vertebrate Gonadotropin-Releasing Hormone, the Type II Isoform, Suggests an Ancient Role for the Metal.2
289419222018The Association of Polymorphisms in the Gene Encoding Gonadotropin-Releasing Hormone with Serum Testosterone Level during Androgen Deprivation Therapy and Prognosis of Metastatic Prostate Cancer.10
289419222018The Association of Polymorphisms in the Gene Encoding Gonadotropin-Releasing Hormone with Serum Testosterone Level during Androgen Deprivation Therapy and Prognosis of Metastatic Prostate Cancer.10
232871102013Gonadotropin-releasing hormone neuropeptides and receptor in human breast cancer: correlation to poor prognosis parameters.6
232871102013Gonadotropin-releasing hormone neuropeptides and receptor in human breast cancer: correlation to poor prognosis parameters.6
21193558201137-kDa laminin receptor precursor mediates GnRH-II-induced MMP-2 expression and invasiveness in ovarian cancer cells.11
212394352011Gonadotropin-releasing hormone-II increases membrane type I metalloproteinase production via beta-catenin signaling in ovarian cancer cells.8
21193558201137-kDa laminin receptor precursor mediates GnRH-II-induced MMP-2 expression and invasiveness in ovarian cancer cells.11

Citation

Dessen P

GNRH2 (gonadotropin releasing hormone 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45598/gnrh2