GNRHR (gonadotropin releasing hormone receptor)

2007-02-01  

Identity

HGNC
LOCATION
4q13.2
LOCUSID
ALIAS
GNRHR1,GRHR,HH7,LHRHR,LRHR

Other Information

Locus ID:

NCBI: 2798
MIM: 138850
HGNC: 4421
Ensembl: ENSG00000109163

Variants:

dbSNP: 2798
ClinVar: 2798
TCGA: ENSG00000109163
COSMIC: GNRHR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109163ENST00000226413P30968
ENSG00000109163ENST00000420975P30968

Expression (GTEx)

0
1
2
3
4
5
6
7

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
GnRH signaling pathwayKEGGko04912
Neuroactive ligand-receptor interactionKEGGhsa04080
GnRH signaling pathwayKEGGhsa04912
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
246851582014Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR.50
186825032008Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome.39
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.38
227781722012GnRH receptors in cancer: from cell biology to novel targeted therapeutic strategies.35
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
151054402004Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect.33
198581972009Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the Ca2+/NFAT signaling pathway decode GnRH pulse frequency?27
206286122010The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane.25
206341972010Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium.25
205079822010Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the ERK signaling pathway decode GnRH pulse frequency?23

Citation

Dessen P

GNRHR (gonadotropin releasing hormone receptor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45941/gnrhr