GOLGA4 (golgin A4)

2003-11-01  

Identity

HGNC
GOLGA4
LOCATION
3p22.2
LOCUSID
2803
ALIAS
CRPF46,GCP2,GOLG,MU-RMS-40.18,p230
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2803
MIM: 602509
HGNC: 4427
Ensembl: ENSG00000144674

Variants:

dbSNP: 2803
ClinVar: 2803
TCGA: ENSG00000144674
COSMIC: GOLGA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000144674ENST00000356847Q13439
ENSG00000144674ENST00000361924Q13439
ENSG00000144674ENST00000429018C9JHJ5
ENSG00000144674ENST00000431105C9J0Y3
ENSG00000144674ENST00000437131H0Y6I0
ENSG00000144674ENST00000444882Q86W71
ENSG00000144674ENST00000450863E7EVX2
ENSG00000144674ENST00000617480A0A087WTW2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
147189282004Structural basis for recruitment of GRIP domain golgin-245 by small GTPase Arl1.38
158701082005tGolgin-1 (p230, golgin-245) modulates Shiga-toxin transport to the Golgi and Golgi motility towards the microtubule-organizing centre.33
183089302008A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo.30
152656872004Interaction between p230 and MACF1 is associated with transport of a glycosyl phosphatidyl inositol-anchored protein from the Golgi to the cell periphery.20
188494892009Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction.13
156547692005The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.11
254364292015Trans-Golgi protein p230/golgin-245 is involved in phagophore formation.4
183946012008Identification of a novel centrosomal protein CrpF46 involved in cell cycle progression and mitosis.0
303054462018Golgin A4 in CSF and granulovacuolar degenerations of patients with Alzheimer disease.0
303361162018The actomyosin network is influenced by NMHC IIA and regulated by Crp<sup>F46</sup>, which is involved in controlling cell migration.0

Citation

Dessen P

GOLGA4 (golgin A4)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40734/golga4