GOPC (golgi associated PDZ and coiled-coil motif containing)

2007-02-01  

Identity

HGNC
LOCATION
6q22.1
LOCUSID
ALIAS
CAL,FIG,GOPC1,PIST,dJ94G16.2
FUSION GENES

Other Information

Locus ID:

NCBI: 57120
MIM: 606845
HGNC: 17643
Ensembl: ENSG00000047932

Variants:

dbSNP: 57120
ClinVar: 57120
TCGA: ENSG00000047932
COSMIC: GOPC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000047932ENST00000052569Q9HD26
ENSG00000047932ENST00000368498Q9HD26
ENSG00000047932ENST00000535237F5H1Y4

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases regulate CFTR traffickingREACTOMER-HSA-5627083

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
333594022021The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells.5
333594022021The ARFRP1-dependent Golgi scaffolding protein GOPC is required for insulin secretion from pancreatic β-cells.5
316262892019GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors.12
316262892019GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors.12
278676662016Plasma Membrane Targeting of Protocadherin 15 Is Regulated by the Golgi-Associated Chaperone Protein PIST.5
278676662016Plasma Membrane Targeting of Protocadherin 15 Is Regulated by the Golgi-Associated Chaperone Protein PIST.5
256146262015The golgi-associated PDZ domain protein PIST/GOPC stabilizes the β1-adrenergic receptor in intracellular compartments after internalization.23
258767032015Regulation of β2-adrenergic receptor cell surface expression by interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL).2
261158682015Role of cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) in regulating the trafficking and signaling of corticotropin-releasing factor receptor 1.2
256146262015The golgi-associated PDZ domain protein PIST/GOPC stabilizes the β1-adrenergic receptor in intracellular compartments after internalization.23
258767032015Regulation of β2-adrenergic receptor cell surface expression by interaction with cystic fibrosis transmembrane conductance regulator-associated ligand (CAL).2
261158682015Role of cystic fibrosis transmembrane conductance regulator-associated ligand (CAL) in regulating the trafficking and signaling of corticotropin-releasing factor receptor 1.2
242107582014Stereochemical preferences modulate affinity and selectivity among five PDZ domains that bind CFTR: comparative structural and sequence analyses.22
249992092014Lack of GOPC-ROS1 (FIG-ROS1) rearrangement in adult human gliomas.3
252310532014Screening for the FIG-ROS1 fusion in biliary tract carcinomas by nested PCR.12

Citation

Dessen P

GOPC (golgi associated PDZ and coiled-coil motif containing)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45928/gopc