Identity
HGNC
LOCATION
10q24.2
LOCUSID
ALIAS
AST1,ASTQTL1,GIG18,cAspAT,cCAT
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2805
MIM: 138180
HGNC: 4432
Ensembl: ENSG00000120053
Variants:
dbSNP: 2805
ClinVar: 2805
TCGA: ENSG00000120053
COSMIC: GOT1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000120053 | ENST00000370508 | P17174 |
| ENSG00000120053 | ENST00000370508 | A0A140VK69 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37752709 | 2024 | Sex Differences in the Association Between AST/ALT and Incidence of Type 2 Diabetes in Japanese Patients with Nonalcoholic Fatty Liver Disease: A Retrospective Cohort Study. | 0 |
| 37752709 | 2024 | Sex Differences in the Association Between AST/ALT and Incidence of Type 2 Diabetes in Japanese Patients with Nonalcoholic Fatty Liver Disease: A Retrospective Cohort Study. | 0 |
| 36497150 | 2022 | Tumor Cell Derived Exosomal GOT1 Suppresses Tumor Cell Ferroptosis to Accelerate Pancreatic Cancer Progression by Activating Nrf2/HO-1 Axis via Upregulating CCR2 Expression. | 6 |
| 36497150 | 2022 | Tumor Cell Derived Exosomal GOT1 Suppresses Tumor Cell Ferroptosis to Accelerate Pancreatic Cancer Progression by Activating Nrf2/HO-1 Axis via Upregulating CCR2 Expression. | 6 |
| 34099767 | 2021 | Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure. | 13 |
| 34315874 | 2021 | GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms. | 10 |
| 34325031 | 2021 | Glutamate-Oxaloacetate Transaminase 1 Impairs Glycolysis by Interacting with Pyruvate Carboxylase and Further Inhibits the Malignant Phenotypes of Glioblastoma Cells. | 2 |
| 34352456 | 2021 | Structural and functional analysis of disease-associated mutations in GOT1 gene: An in silico study. | 2 |
| 34381026 | 2021 | GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. | 99 |
| 34099767 | 2021 | Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure. | 13 |
| 34315874 | 2021 | GWAS of serum ALT and AST reveals an association of SLC30A10 Thr95Ile with hypermanganesemia symptoms. | 10 |
| 34325031 | 2021 | Glutamate-Oxaloacetate Transaminase 1 Impairs Glycolysis by Interacting with Pyruvate Carboxylase and Further Inhibits the Malignant Phenotypes of Glioblastoma Cells. | 2 |
| 34352456 | 2021 | Structural and functional analysis of disease-associated mutations in GOT1 gene: An in silico study. | 2 |
| 34381026 | 2021 | GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis. | 99 |
| 32157800 | 2020 | Clinical implications of aminotransferase elevation in hospitalised infants aged 8-90 days with respiratory virus detection. | 1 |
Citation
Dessen P
GOT1 (glutamic-oxaloacetic transaminase 1)
Atlas Genet Cytogenet Oncol Haematol. 2007-06-01
Online version: http://atlasgeneticsoncology.org/gene/43000/got1
