GP6 (glycoprotein VI platelet)

2014-11-01 Affiliation

Identity

HGNC

GP6

LOCATION

19q13.42

LOCUSID

51206

ALIAS

BDPLT11,GPIV,GPVI

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51206
MIM: 605546
HGNC: 14388
Ensembl: ENSG00000088053

Variants:

dbSNP: 51206
ClinVar: 51206
TCGA: ENSG00000088053
COSMIC: GP6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000088053	ENST00000310373	Q9HCN6
ENSG00000088053	ENST00000333884	Q9HCN6
ENSG00000088053	ENST00000417454	Q9HCN6
ENSG00000088053	ENST00000468239	K7EIW7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ECM-receptor interaction	KEGG	ko04512
ECM-receptor interaction	KEGG	hsa04512
Platelet activation	KEGG	hsa04611
Hemostasis	REACTOME	R-HSA-109582
Platelet Adhesion to exposed collagen	REACTOME	R-HSA-75892
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
GPVI-mediated activation cascade	REACTOME	R-HSA-114604
Cell surface interactions at the vascular wall	REACTOME	R-HSA-202733

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA26716	COL3A1	Gene	Pathway	associated		20938371
PA26717	COL4A1	Gene	Pathway	associated		20938371
PA26718	COL4A2	Gene	Pathway	associated		20938371
PA33384	PLCB1	Gene	Pathway	associated		20938371
PA33393	PLCG2	Gene	Pathway	associated		20938371
PA35041	COL1A1	Gene	Pathway	associated		20938371
PA35042	COL1A2	Gene	Pathway	associated		20938371
PA443796	Coronary Artery Disease	Disease	ClinicalAnnotation	associated	PD	16493486
PA448497	aspirin	Chemical	ClinicalAnnotation	associated	PD	16493486

References

Pubmed ID	Year	Title	Citations
12649139	2003	Platelet-collagen interaction: is GPVI the central receptor?	211
16102042	2005	GPVI and integrin alphaIIb beta3 signaling in platelets.	130
19278955	2009	Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach.	88
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
10506151	1999	The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptors.	54
25977585	2015	Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation.	44
16219796	2006	Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.	42
15456756	2004	Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.	41
17085439	2007	Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets.	40

Citation

Dessen P

GP6 (glycoprotein VI platelet)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63918/gp6