GPC4 (glypican 4)

2003-05-01  

Identity

HGNC
LOCATION
Xq26.2
LOCUSID
ALIAS
K-glypican,KPTS
FUSION GENES

Other Information

Locus ID:

NCBI: 2239
MIM: 300168
HGNC: 4452
Ensembl: ENSG00000076716

Variants:

dbSNP: 2239
ClinVar: 2239
TCGA: ENSG00000076716
COSMIC: GPC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000076716ENST00000370828O75487

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Wnt signaling pathwayKEGGhsa04310
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with glycosaminoglycan metabolismREACTOMER-HSA-3560782
Defective B4GALT7 causes EDS, progeroid typeREACTOMER-HSA-3560783
Defective B3GAT3 causes JDSSDHDREACTOMER-HSA-3560801
Defective EXT1 causes exostoses 1, TRPS2 and CHDSREACTOMER-HSA-3656253
Defective EXT2 causes exostoses 2REACTOMER-HSA-3656237
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Heparan sulfate/heparin (HS-GAG) metabolismREACTOMER-HSA-1638091
A tetrasaccharide linker sequence is required for GAG synthesisREACTOMER-HSA-1971475
HS-GAG biosynthesisREACTOMER-HSA-2022928
HS-GAG degradationREACTOMER-HSA-2024096
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Defective B3GALT6 causes EDSP2 and SEMDJL1REACTOMER-HSA-4420332
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
227610132012Modulating Glypican4 suppresses tumorigenicity of embryonic stem cells while preserving self-renewal and pluripotency.10
226443262012MicroRNA-125a inhibits cell growth by targeting glypican-4.6
314849222019CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis.5
270718542016Glypican-4 gene polymorphism (rs1048369) and susceptibility to Epstein-Barr virus-associated and -negative gastric carcinoma.3
264863092016Association of serum glypican-4 levels with cardiovascular risk predictors in women with polycystic ovary syndrome - a pilot study.2
274252502016Expression of Glypican-4 in the brains of epileptic patients and epileptic animals and its effects on epileptic seizures.2
309826112019Pathogenic Variants in GPC4 Cause Keipert Syndrome.2
236331952013Association of glypican-4 with body fat distribution, insulin resistance, and nonalcoholic fatty liver disease.0
312170572019Serum Glypican 4 Levels Are Associated with Metabolic Syndrome in a Han Population from Guizhou Province, China.0
315221692019The Glypican-4 Gene Polymorphism rs1048369 and Susceptibility to Epstein-Barr Virus-Positive and -Negative Nasopharyngeal Carcinoma in Northern China.0

Citation

Dessen P

GPC4 (glypican 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40736/gpc4