Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GPD1L (glycerol-3-phosphate dehydrogenase 1 like)

Identity

Alias_symbol (synonym)KIAA0089
Other aliasGPD1-L
HGNC (Hugo) GPD1L
LocusID (NCBI) 23171
Atlas_Id 54913
Location 3p22.3  [Link to chromosome band 3p22]
Location_base_pair Starts at 32106511 and ends at 32168715 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EDEM1 (3p26.1) / GPD1L (3p22.3)GPD1L (3p22.3) / EDEM1 (3p26.1)GPD1L (3p22.3) / STT3B (3p23)
GPD1L (3p22.3) / UBE2G1 (17p13.2)OSBPL10 (3p23) / GPD1L (3p22.3)TMEM135 (11q14.2) / GPD1L (3p22.3)
ZEB2 (2q22.3) / GPD1L (3p22.3)EDEM1 3p26.1 / GPD1L 3p22.3GPD1L 3p22.3 / STT3B 3p23
OSBPL10 3p23 / GPD1L 3p22.3TMEM135 11q14.2 / GPD1L 3p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  OSBPL10/GPD1L (3p22)
t(3;3)(p22;p23) GPD1L/STT3B
t(3;3)(p22;p26) EDEM1/GPD1L
t(3;11)(p22;q14) TMEM135/GPD1L

External links

Nomenclature
HGNC (Hugo)GPD1L   28956
LRG (Locus Reference Genomic)LRG_419
Cards
Entrez_Gene (NCBI)GPD1L  23171  glycerol-3-phosphate dehydrogenase 1 like
AliasesGPD1-L
GeneCards (Weizmann)GPD1L
Ensembl hg19 (Hinxton)ENSG00000152642 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152642 [Gene_View]  ENSG00000152642 [Sequence]  chr3:32106511-32168715 [Contig_View]  GPD1L [Vega]
ICGC DataPortalENSG00000152642
TCGA cBioPortalGPD1L
AceView (NCBI)GPD1L
Genatlas (Paris)GPD1L
WikiGenes23171
SOURCE (Princeton)GPD1L
Genetics Home Reference (NIH)GPD1L
Genomic and cartography
GoldenPath hg38 (UCSC)GPD1L  -     chr3:32106511-32168715 +  3p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPD1L  -     3p22.3   [Description]    (hg19-Feb_2009)
GoldenPathGPD1L - 3p22.3 [CytoView hg19]  GPD1L - 3p22.3 [CytoView hg38]
ImmunoBaseENSG00000152642
Mapping of homologs : NCBIGPD1L [Mapview hg19]  GPD1L [Mapview hg38]
OMIM611777   611778   
Gene and transcription
Genbank (Entrez)AI080105 AK074221 AK125404 AK292808 BC006168
RefSeq transcript (Entrez)NM_015141
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GPD1L
Cluster EST : UnigeneHs.82432 [ NCBI ]
CGAP (NCI)Hs.82432
Alternative Splicing GalleryENSG00000152642
Gene ExpressionGPD1L [ NCBI-GEO ]   GPD1L [ EBI - ARRAY_EXPRESS ]   GPD1L [ SEEK ]   GPD1L [ MEM ]
Gene Expression Viewer (FireBrowse)GPD1L [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23171
GTEX Portal (Tissue expression)GPD1L
Human Protein AtlasENSG00000152642-GPD1L [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N335   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N335  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N335
Splice isoforms : SwissVarQ8N335
PhosPhoSitePlusQ8N335
Domains : Interpro (EBI)6-PGluconate_DH-like_C_sf    6PGD_dom2    G3P_DH_NAD-dep    G3P_DH_NAD-dep_C    G3P_DH_NAD-dep_euk    G3P_DH_NAD-dep_N    NAD(P)-bd_dom_sf   
Domain families : Pfam (Sanger)NAD_Gly3P_dh_C (PF07479)    NAD_Gly3P_dh_N (PF01210)   
Domain families : Pfam (NCBI)pfam07479    pfam01210   
Conserved Domain (NCBI)GPD1L
DMDM Disease mutations23171
Blocks (Seattle)GPD1L
PDB (RSDB)2PLA   
PDB Europe2PLA   
PDB (PDBSum)2PLA   
PDB (IMB)2PLA   
Structural Biology KnowledgeBase2PLA   
SCOP (Structural Classification of Proteins)2PLA   
CATH (Classification of proteins structures)2PLA   
SuperfamilyQ8N335
Human Protein Atlas [tissue]ENSG00000152642-GPD1L [tissue]
Peptide AtlasQ8N335
HPRD10008
IPIIPI00032959   IPI00926212   IPI00926439   IPI00926599   IPI00926831   
Protein Interaction databases
DIP (DOE-UCLA)Q8N335
IntAct (EBI)Q8N335
FunCoupENSG00000152642
BioGRIDGPD1L
STRING (EMBL)GPD1L
ZODIACGPD1L
Ontologies - Pathways
QuickGOQ8N335
Ontology : AmiGOregulation of heart rate  glycerol-3-phosphate dehydrogenase [NAD+] activity  cytosol  cytosol  plasma membrane  carbohydrate metabolic process  NADH oxidation  phosphatidic acid biosynthetic process  glycerol-3-phosphate dehydrogenase complex  positive regulation of sodium ion transport  sodium channel regulator activity  NAD metabolic process  negative regulation of peptidyl-serine phosphorylation  protein homodimerization activity  ion channel binding  glycerol-3-phosphate catabolic process  NAD binding  regulation of ventricular cardiac muscle cell membrane depolarization  extracellular exosome  ventricular cardiac muscle cell action potential  negative regulation of protein kinase C signaling  positive regulation of protein localization to cell surface  regulation of sodium ion transmembrane transporter activity  
Ontology : EGO-EBIregulation of heart rate  glycerol-3-phosphate dehydrogenase [NAD+] activity  cytosol  cytosol  plasma membrane  carbohydrate metabolic process  NADH oxidation  phosphatidic acid biosynthetic process  glycerol-3-phosphate dehydrogenase complex  positive regulation of sodium ion transport  sodium channel regulator activity  NAD metabolic process  negative regulation of peptidyl-serine phosphorylation  protein homodimerization activity  ion channel binding  glycerol-3-phosphate catabolic process  NAD binding  regulation of ventricular cardiac muscle cell membrane depolarization  extracellular exosome  ventricular cardiac muscle cell action potential  negative regulation of protein kinase C signaling  positive regulation of protein localization to cell surface  regulation of sodium ion transmembrane transporter activity  
Pathways : KEGGGlycerophospholipid metabolism   
NDEx NetworkGPD1L
Atlas of Cancer Signalling NetworkGPD1L
Wikipedia pathwaysGPD1L
Orthology - Evolution
OrthoDB23171
GeneTree (enSembl)ENSG00000152642
Phylogenetic Trees/Animal Genes : TreeFamGPD1L
HOGENOMQ8N335
Homologs : HomoloGeneGPD1L
Homology/Alignments : Family Browser (UCSC)GPD1L
Gene fusions - Rearrangements
Fusion : MitelmanEDEM1/GPD1L [3p26.1/3p22.3]  [t(3;3)(p22;p26)]  
Fusion : MitelmanGPD1L/STT3B [3p22.3/3p23]  [t(3;3)(p22;p23)]  
Fusion : MitelmanOSBPL10/GPD1L [3p23/3p22.3]  [t(3;3)(p22;p22)]  
Fusion : MitelmanTMEM135/GPD1L [11q14.2/3p22.3]  [t(3;11)(p22;q14)]  
Fusion PortalEDEM1 3p26.1 GPD1L 3p22.3 PRAD
Fusion PortalGPD1L 3p22.3 STT3B 3p23 BLCA
Fusion PortalOSBPL10 3p23 GPD1L 3p22.3 BLCA
Fusion PortalTMEM135 11q14.2 GPD1L 3p22.3 LGG
Fusion : QuiverGPD1L
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPD1L [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPD1L
dbVarGPD1L
ClinVarGPD1L
1000_GenomesGPD1L 
Exome Variant ServerGPD1L
ExAC (Exome Aggregation Consortium)ENSG00000152642
GNOMAD BrowserENSG00000152642
Varsome BrowserGPD1L
Genetic variants : HAPMAP23171
Genomic Variants (DGV)GPD1L [DGVbeta]
DECIPHERGPD1L [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPD1L 
Mutations
ICGC Data PortalGPD1L 
TCGA Data PortalGPD1L 
Broad Tumor PortalGPD1L
OASIS PortalGPD1L [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPD1L  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGPD1L
Mutations and Diseases : HGMDGPD1L
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GPD1L
DgiDB (Drug Gene Interaction Database)GPD1L
DoCM (Curated mutations)GPD1L (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPD1L (select a term)
intoGenGPD1L
Cancer3DGPD1L(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611777    611778   
Orphanet8022   
DisGeNETGPD1L
MedgenGPD1L
Genetic Testing Registry GPD1L
NextProtQ8N335 [Medical]
TSGene23171
GENETestsGPD1L
Target ValidationGPD1L
Huge Navigator GPD1L [HugePedia]
snp3D : Map Gene to Disease23171
BioCentury BCIQGPD1L
ClinGenGPD1L
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23171
Chemical/Pharm GKB GenePA134986345
Clinical trialGPD1L
Miscellaneous
canSAR (ICR)GPD1L (select the gene name)
DataMed IndexGPD1L
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPD1L
EVEXGPD1L
GoPubMedGPD1L
iHOPGPD1L
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:45:26 CET 2019
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