GPD2 (glycerol-3-phosphate dehydrogenase 2)

2007-02-01  

Identity

HGNC
GPD2
LOCATION
2q24.1
LOCUSID
2820
ALIAS
GDH2,GPDM,mGDH,mGPDH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2820
MIM: 138430
HGNC: 4456
Ensembl: ENSG00000115159

Variants:

dbSNP: 2820
ClinVar: 2820
TCGA: ENSG00000115159
COSMIC: GPD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115159ENST00000310454P43304
ENSG00000115159ENST00000409125P43304
ENSG00000115159ENST00000409674P43304
ENSG00000115159ENST00000409861P43304
ENSG00000115159ENST00000415049E7EM56
ENSG00000115159ENST00000416888E9PDK4
ENSG00000115159ENST00000430992E9PDK4
ENSG00000115159ENST00000438166P43304
ENSG00000115159ENST00000540309F5GYK7

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Glycerophospholipid metabolismKEGGhsa00564
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
159674082005High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines.17
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
178860332007Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer.13
112437262001A sequence variation in the mitochondrial glycerol-3-phosphate dehydrogenase gene is associated with increased plasma glycerol and free fatty acid concentrations among French Canadians.5
297704302018NR4A2 haploinsufficiency is associated with intellectual disability and autism spectrum disorder.4
303896812018Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration.3
154567632004Germ cell nuclear factor relieves cAMP-response element modulator tau-mediated activation of the testis-specific promoter of human mitochondrial glycerol-3-phosphate dehydrogenase.2
306536872019Deficiency of Mitochondrial Glycerol 3-Phosphate Dehydrogenase Contributes to Hepatic Steatosis.2

Citation

Dessen P

GPD2 (glycerol-3-phosphate dehydrogenase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43732/gpd2