GPHA2 (glycoprotein hormone subunit alpha 2)

2014-11-01  

Identity

HGNC
GPHA2
LOCATION
11q13.1
LOCUSID
170589
ALIAS
A2,GPA2,ZSIG51

Other Information

Locus ID:

NCBI: 170589
MIM: 609651
HGNC: 18054
Ensembl: ENSG00000149735

Variants:

dbSNP: 170589
ClinVar: 170589
TCGA: ENSG00000149735
COSMIC: GPHA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149735ENST00000279168Q96T91
ENSG00000149735ENST00000279168A0A024R579
ENSG00000149735ENST00000532246E9PLQ0
ENSG00000149735ENST00000533257Q96T91
ENSG00000149735ENST00000533257A0A024R579

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

References

Pubmed IDYearTitleCitations
118099712002Activation of orphan receptors by the hormone relaxin.144
158907692005Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5.26
120893492002Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5.24
260182492015Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development.11
184338982008Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5).10
163764812005Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit.1
173630772007The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin.0

Citation

Dessen P

GPHA2 (glycoprotein hormone subunit alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63935/gpha2