GPI (glucose-6-phosphate isomerase)

2003-02-01  

Identity

HGNC
LOCATION
19q13.11
LOCUSID
ALIAS
AMF,GNPI,NLK,PGI,PHI,SA-36,SA36
FUSION GENES

Other Information

Locus ID:

NCBI: 2821
MIM: 172400
HGNC: 4458
Ensembl: ENSG00000105220

Variants:

dbSNP: 2821
ClinVar: 2821
TCGA: ENSG00000105220
COSMIC: GPI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105220ENST00000356487P06744
ENSG00000105220ENST00000415930A0A2U3TZU2
ENSG00000105220ENST00000586425K7EQ48
ENSG00000105220ENST00000587384K7ERK8
ENSG00000105220ENST00000587521K7EIL4
ENSG00000105220ENST00000588991P06744
ENSG00000105220ENST00000589399K7ERC6
ENSG00000105220ENST00000589640K7EPY4
ENSG00000105220ENST00000590375K7EP41
ENSG00000105220ENST00000591204K7ENA0
ENSG00000105220ENST00000592144A0A0G2JLI6
ENSG00000105220ENST00000592277K7ELR7
ENSG00000105220ENST00000642240A0A2R8YF08
ENSG00000105220ENST00000647446A0A2R8Y6C7

Expression (GTEx)

0
50
100
150
200
250
300
350
400

Pathways

PathwaySourceExternal ID
Glycolysis / GluconeogenesisKEGGko00010
Pentose phosphate pathwayKEGGko00030
Starch and sucrose metabolismKEGGko00500
Amino sugar and nucleotide sugar metabolismKEGGko00520
Glycolysis / GluconeogenesisKEGGhsa00010
Pentose phosphate pathwayKEGGhsa00030
Starch and sucrose metabolismKEGGhsa00500
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGhsa_M00001
Pentose phosphate pathway (Pentose phosphate cycle)KEGGhsa_M00004
Glycolysis (Embden-Meyerhof pathway), glucose => pyruvateKEGGM00001
Pentose phosphate pathway (Pentose phosphate cycle)KEGGM00004
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GlycolysisREACTOMER-HSA-70171
GluconeogenesisREACTOMER-HSA-70263
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
215555182011The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.60
150340672004Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice.51
183117882008Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase.41
195316502009Phosphoglucose isomerase/autocrine motility factor mediates epithelial and mesenchymal phenotype conversions in breast cancer.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
125178042003Overexpression of the autocrine motility factor/phosphoglucose isomerase induces transformation and survival of NIH-3T3 fibroblasts.23
145668192003Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression.23
110045672000Phosphohexose isomerase/autocrine motility factor/neuroleukin/maturation factor is a multifunctional phosphoprotein.22
155700122004Autocrine motility factor signaling enhances pancreatic cancer metastasis.21
116889912001Identification of genes differentially induced by hypoxia in pancreatic cancer cells.20

Citation

Dessen P

GPI (glucose-6-phosphate isomerase)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40737/gpi