GPR119 (G protein-coupled receptor 119)

2014-11-01 Affiliation

Identity

HGNC

GPR119

LOCATION

Xq26.1

LOCUSID

139760

ALIAS

GPCR2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 139760
MIM: 300513
HGNC: 19060
Ensembl: ENSG00000147262

Variants:

dbSNP: 139760
ClinVar: 139760
TCGA: ENSG00000147262
COSMIC: GPR119

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000147262	ENST00000276218	Q8TDV5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Insulin secretion	KEGG	hsa04911
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Incretin synthesis, secretion, and inactivation	REACTOME	R-HSA-400508
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	REACTOME	R-HSA-381771
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)	REACTOME	R-HSA-400511

References

Pubmed ID	Year	Title	Citations
16517404	2006	Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents.	158
19920139	2010	A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors.	48
24493833	2014	A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.	34
19901198	2010	N-oleoyldopamine enhances glucose homeostasis through the activation of GPR119.	23
23798572	2013	Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine L-cell line GLUTag.	12
22883930	2013	GPR119 expression in normal human tissues and islet cell tumors: evidence for its islet-gastrointestinal distribution, expression in pancreatic beta and alpha cells, and involvement in islet function.	11
23897163	2014	Novel GPR119 agonist HD0471042 attenuated type 2 diabetes mellitus.	5
27391814	2016	Angelica dahurica Extracts Improve Glucose Tolerance through the Activation of GPR119.	4
23069642	2013	GPR119 regulates genetic markers of fatty acid oxidation in cultured skeletal muscle myotubes.	3
24681896	2014	Discovery and characterization of novel small molecule agonists of G protein-coupled receptor 119.	2

Citation

Dessen P

GPR119 (G protein-coupled receptor 119)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63949/gpr119