GPR18 (G protein-coupled receptor 18)

2011-04-01  

Identity

HGNC
GPR18
LOCATION
13q32.3
LOCUSID
2841
ALIAS
-

Other Information

Locus ID:

NCBI: 2841
MIM: 602042
HGNC: 4472
Ensembl: ENSG00000125245

Variants:

dbSNP: 2841
ClinVar: 2841
TCGA: ENSG00000125245
COSMIC: GPR18

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125245ENST00000340807Q14330
ENSG00000125245ENST00000340807H9NIM1
ENSG00000125245ENST00000397470Q14330
ENSG00000125245ENST00000397470H9NIM1
ENSG00000125245ENST00000397473Q14330
ENSG00000125245ENST00000397473H9NIM1
ENSG00000125245ENST00000416594Q5JUH9

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
261957252015Identification of resolvin D2 receptor mediating resolution of infections and organ protection.98
168440832006Identification of N-arachidonylglycine as the endogenous ligand for orphan G-protein-coupled receptor GPR18.84
247620582014Activation of GPR18 by cannabinoid compounds: a tale of biased agonism.38
208801982011Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target.32
275729372016Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18.5
298707112018Molecular and functional interaction between GPR18 and cannabinoid CB<sub>2</sub> G-protein-coupled receptors. Relevance in neurodegenerative diseases.5
212615962011EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors.4
310759332019Towards A Molecular Understanding of The Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity.3
305037222019GPR18 expression on PMNs as biomarker for outcome in patient with sepsis.2

Citation

Dessen P

GPR18 (G protein-coupled receptor 18)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52180/gpr18