GPR182 (G protein-coupled receptor 182)

2010-03-01  

Identity

HGNC
GPR182
LOCATION
12q13.3
LOCUSID
11318
ALIAS
7TMR,ADMR,AM-R,AMR,G10D,L1-R,gamrh,hrhAMR

Other Information

Locus ID:

NCBI: 11318
MIM: 605307
HGNC: 13708
Ensembl: ENSG00000166856

Variants:

dbSNP: 11318
ClinVar: 11318
TCGA: ENSG00000166856
COSMIC: GPR182

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166856ENST00000300098O15218
ENSG00000166856ENST00000556850A0A0D9SG31
ENSG00000166856ENST00000622922Q7Z4H2

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA24580ADMGenePathwayassociated

References

Pubmed IDYearTitleCitations
95357521998Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response.10
198472982009The ADMR receptor mediates the effects of adrenomedullin on pancreatic cancer cells and on cells of the tumor microenvironment.9
179396012007Localization and distribution of adrenomedullin receptor in the human placenta: changes with gestational age.5
119566482002The cardiovascular response in sepsis: proposed mechanisms of the beneficial effect of adrenomedullin and its binding protein (review).3
124195222002Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats.2
234423652013Intermedin in rat uterus: changes in gene expression and peptide levels across the estrous cycle and its effects on uterine contraction.2
294085022018GPR182 is a novel marker for sinusoidal endothelial differentiation with distinct GPCR signaling activity in vitro.2
117120852001Expression and function of adrenomedullin and its receptors in Conn's adenoma cells.1
126462142003Expression of adrenomedullin and its receptor by chondrocyte phenotype cells.0
147204322003[Study of the expression and role of adrenomedullin and adrenomedullin receptor in patients with chronic obstructive pulmonary disease].0

Citation

Dessen P

GPR182 (G protein-coupled receptor 182)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51391/gpr182