GPR183 (G protein-coupled receptor 183)

2016-10-01  

Identity

HGNC
GPR183
LOCATION
13q32.3
LOCUSID
1880
ALIAS
EBI2,hEBI2

Other Information

Locus ID:

NCBI: 1880
MIM: 605741
HGNC: 3128
Ensembl: ENSG00000169508

Variants:

dbSNP: 1880
ClinVar: 1880
TCGA: ENSG00000169508
COSMIC: GPR183

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169508ENST00000376414P32249
ENSG00000169508ENST00000376414A0A024RDX2

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
165404622006Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity.35
186284022008Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist.13
228758552012Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183).12
229138782012EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5.10
244804422014Transcriptional regulation and functional characterization of the oxysterol/EBI2 system in primary human macrophages.10
252978972015EBI2 regulates intracellular signaling and migration in human astrocyte.9
229307112012Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site.8
280522502017EBI2 Expression and Function: Robust in Memory Lymphocytes and Increased by Natalizumab in Multiple Sclerosis.6
307420432019The EBI2-oxysterol axis promotes the development of intestinal lymphoid structures and colitis.6
212615962011EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors.4

Citation

Dessen P

GPR183 (G protein-coupled receptor 183)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56392/gpr183