GPR55 (G protein-coupled receptor 55)

2011-03-01 Affiliation

Identity

HGNC

GPR55

LOCATION

2q37.1

LOCUSID

9290

ALIAS

LPIR1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9290
MIM: 604107
HGNC: 4511
Ensembl: ENSG00000135898

Variants:

dbSNP: 9290
ClinVar: 9290
TCGA: ENSG00000135898
COSMIC: GPR55

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135898	ENST00000392039	Q9Y2T6
ENSG00000135898	ENST00000392039	A8K858
ENSG00000135898	ENST00000392040	Q9Y2T6
ENSG00000135898	ENST00000392040	A8K858
ENSG00000135898	ENST00000438398	C9J1P7
ENSG00000135898	ENST00000444078	Q9Y2T6
ENSG00000135898	ENST00000444078	A8K858
ENSG00000135898	ENST00000622008	Q9Y2T6
ENSG00000135898	ENST00000622008	A8K858
ENSG00000135898	ENST00000650999	Q9Y2T6
ENSG00000135898	ENST00000650999	A8K858

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

References

Pubmed ID	Year	Title	Citations
17876302	2007	The orphan receptor GPR55 is a novel cannabinoid receptor.	397
18263732	2008	GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current.	186
17765871	2007	Identification of GPR55 as a lysophosphatidylinositol receptor.	127
18757503	2009	The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation.	89
19805329	2009	The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo.	89
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19723626	2009	Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.	83
20838378	2011	The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation.	66
20818416	2011	The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.	61
18445684	2008	Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression.	56

Citation

Dessen P

GPR55 (G protein-coupled receptor 55)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52097/gpr55