GPR83 (G protein-coupled receptor 83)

2014-11-01 Affiliation

Identity

HGNC

GPR83

LOCATION

11q21

LOCUSID

10888

ALIAS

GIR,GPR72

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10888
MIM: 605569
HGNC: 4523
Ensembl: ENSG00000123901

Variants:

dbSNP: 10888
ClinVar: 10888
TCGA: ENSG00000123901
COSMIC: GPR83

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000123901	ENST00000243673	Q9NYM4
ENSG00000123901	ENST00000539203	F5GZ43

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD
PA447288	Essential hypertension	Disease	ClinicalAnnotation	associated	PD
PA448765	candesartan	Chemical	ClinicalAnnotation	associated	PD
PA449899	hydrochlorothiazide	Chemical	ClinicalAnnotation	associated	PD

References

Pubmed ID	Year	Title	Citations
16785516	2006	G protein-coupled receptor 83 overexpression in naive CD4+CD25- T cells leads to the induction of Foxp3+ regulatory T cells in vivo.	20
20200545	2010	Inflammation in vivo is modulated by GPR83 isoform-4 but not GPR83 isoform-1 expression in regulatory T cells.	9

Citation

Dessen P

GPR83 (G protein-coupled receptor 83)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64008/gpr83