GPS1 (G protein pathway suppressor 1)

2007-04-01  

Identity

HGNC
GPS1
LOCATION
17q25.3
LOCUSID
2873
ALIAS
COPS1,CSN1,SGN1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2873
MIM: 601934
HGNC: 4549
Ensembl: ENSG00000169727

Variants:

dbSNP: 2873
ClinVar: 2873
TCGA: ENSG00000169727
COSMIC: GPS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169727ENST00000306823Q13098
ENSG00000169727ENST00000320548C9JFE4
ENSG00000169727ENST00000392358Q13098
ENSG00000169727ENST00000578168J3QQX0
ENSG00000169727ENST00000578392J3KSY1
ENSG00000169727ENST00000578552Q13098
ENSG00000169727ENST00000580141J3KRY5
ENSG00000169727ENST00000580627J3QQP2
ENSG00000169727ENST00000580716J3QLT0
ENSG00000169727ENST00000580723J3KRY5
ENSG00000169727ENST00000581418J3KTB0
ENSG00000169727ENST00000581578J3QS84
ENSG00000169727ENST00000582327J3QS88
ENSG00000169727ENST00000583009J3QLE8
ENSG00000169727ENST00000583641J3KRJ4
ENSG00000169727ENST00000583885J3KRE8
ENSG00000169727ENST00000583961J3QL53
ENSG00000169727ENST00000584460J3KRY5
ENSG00000169727ENST00000585084J3KSA5
ENSG00000169727ENST00000623691A0A096LP07
ENSG00000169727ENST00000623761A8K070
ENSG00000169727ENST00000624957A0A096LPJ3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
DNA RepairREACTOMER-HSA-73894
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
Transcription-Coupled Nucleotide Excision Repair (TC-NER)REACTOMER-HSA-6781827
Formation of TC-NER Pre-Incision ComplexREACTOMER-HSA-6781823
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

References

Pubmed IDYearTitleCitations
382894962024Bioinformatics analysis of GPS1 expression and biological function in breast cancer.0
382894962024Bioinformatics analysis of GPS1 expression and biological function in breast cancer.0
332008032021CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression.8
332008032021CSN1 facilitates proliferation and migration of hepatocellular carcinoma cells by upregulating cyclin A2 expression.8
269860082016UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis.4
273256502016CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.22
269860082016UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis.4
273256502016CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma.22
234089082013Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome.25
234089082013Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome.25
221037472012Altered expression of COP9 signalosome proteins in preeclampsia.5
221037472012Altered expression of COP9 signalosome proteins in preeclampsia.5
216041932011CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1.5
216041932011CSN1 inhibits c-Jun phosphorylation and down-regulates ectopic expression of JNK1.5
111142422001The subunit 1 of the COP9 signalosome suppresses gene expression through its N-terminal domain and incorporates into the complex through the PCI domain.36

Citation

Dessen P

GPS1 (G protein pathway suppressor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47118/gps1