GPS2 (G protein pathway suppressor 2)

2014-01-01  

Identity

HGNC
LOCATION
17p13.1
LOCUSID
ALIAS
AMF-1
FUSION GENES

Other Information

Locus ID:

NCBI: 2874
MIM: 601935
HGNC: 4550
Ensembl: ENSG00000132522

Variants:

dbSNP: 2874
ClinVar: 2874
TCGA: ENSG00000132522
COSMIC: GPS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132522ENST00000380728Q13227
ENSG00000132522ENST00000389167Q13227
ENSG00000132522ENST00000570780I3L3Y9
ENSG00000132522ENST00000573684I3L1H4
ENSG00000132522ENST00000574458I3L242
ENSG00000132522ENST00000577040I3L4X7

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDACs deacetylate histonesREACTOMER-HSA-3214815

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
119317682002The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.192
201599572010GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRbeta in the hepatic acute phase response.71
194815302009GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.42
178953792007Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis.37
232213462013SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation.24
198582092009G protein pathway suppressor 2 (GPS2) is a transcriptional corepressor important for estrogen receptor alpha-mediated transcriptional regulation.20
294991322018Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation.20
161229922006Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for subsequent GPS2 recruitment.19
272705892016Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes.18
182186302008G-protein pathway suppressor 2 (GPS2) interacts with the regulatory factor X4 variant 3 (RFX4_v3) and functions as a transcriptional co-activator.17

Citation

Dessen P

GPS2 (G protein pathway suppressor 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53670/gps2