GPSM2 (G protein signaling modulator 2)

2007-04-01  

Identity

HGNC
GPSM2
LOCATION
1p13.3
LOCUSID
29899
ALIAS
CMCS,DFNB82,LGN,PINS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29899
MIM: 609245
HGNC: 29501
Ensembl: ENSG00000121957

Variants:

dbSNP: 29899
ClinVar: 29899
TCGA: ENSG00000121957
COSMIC: GPSM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121957ENST00000264126P81274
ENSG00000121957ENST00000264126A0A024R0F8
ENSG00000121957ENST00000406462P81274
ENSG00000121957ENST00000406462A0A024R0F8
ENSG00000121957ENST00000435475B0QZD0
ENSG00000121957ENST00000435987Q5T1N9
ENSG00000121957ENST00000441735H0Y4A4
ENSG00000121957ENST00000446797B0QZC9
ENSG00000121957ENST00000642355P81274
ENSG00000121957ENST00000642355A0A024R0F8
ENSG00000121957ENST00000643094A0A2R8Y673
ENSG00000121957ENST00000643643A0A2R8Y6E3
ENSG00000121957ENST00000645164A0A2R8Y896
ENSG00000121957ENST00000645255A0A2R8YCX1

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206029142010Whole exome sequencing and homozygosity mapping identify mutation in the cell polarity protein GPSM2 as the cause of nonsyndromic hearing loss DFNB82.125
209334262010Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins.108
204791292010Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.79
118324912002Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis.48
225783262012GPSM2 mutations cause the brain malformations and hearing loss in Chudley-McCullough syndrome.37
280451172017Cell division orientation is coupled to cell-cell adhesion by the E-cadherin/LGN complex.29
220748472011Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN).26
233896352013Evidence for dynein and astral microtubule-mediated cortical release and transport of Gαi/LGN/NuMA complex in mitotic cells.24
156322022005Direct binding of Lgl2 to LGN during mitosis and its requirement for normal cell division.22
267516422016Concomitant binding of Afadin to LGN and F-actin directs planar spindle orientation.22

Citation

Dessen P

GPSM2 (G protein signaling modulator 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47143/gpsm2