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GPSM2 (G-protein signaling modulator 2)

Identity

Other namesCMCS
DFNB82
LGN
PINS
HGNC (Hugo) GPSM2
LocusID (NCBI) 29899
Atlas_Id 47143
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at 109419603 and ends at 109473044 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GPSM2 (1p13.3) / CHP2 (16p12.2)MTF2 (1p22.1) / GPSM2 (1p13.3)MTF2 1p22.1 / GPSM2 1p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GPSM2   29501
Cards
Entrez_Gene (NCBI)GPSM2  29899  G-protein signaling modulator 2
AliasesCMCS; DFNB82; LGN; PINS
GeneCards (Weizmann)GPSM2
Ensembl hg19 (Hinxton)ENSG00000121957 [Gene_View]  chr1:109419603-109473044 [Contig_View]  GPSM2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000121957 [Gene_View]  chr1:109419603-109473044 [Contig_View]  GPSM2 [Vega]
ICGC DataPortalENSG00000121957
TCGA cBioPortalGPSM2
AceView (NCBI)GPSM2
Genatlas (Paris)GPSM2
WikiGenes29899
SOURCE (Princeton)GPSM2
Genomic and cartography
GoldenPath hg19 (UCSC)GPSM2  -     chr1:109419603-109473044 +  1p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GPSM2  -     1p13.3   [Description]    (hg38-Dec_2013)
EnsemblGPSM2 - 1p13.3 [CytoView hg19]  GPSM2 - 1p13.3 [CytoView hg38]
Mapping of homologs : NCBIGPSM2 [Mapview hg19]  GPSM2 [Mapview hg38]
OMIM604213   609245   
Gene and transcription
Genbank (Entrez)AB445462 AI224972 AK295563 AK314249 AY136740
RefSeq transcript (Entrez)NM_001321038 NM_001321039 NM_013296
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_028108 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)GPSM2
Cluster EST : UnigeneHs.658489 [ NCBI ]
CGAP (NCI)Hs.658489
Alternative Splicing GalleryENSG00000121957
Gene ExpressionGPSM2 [ NCBI-GEO ]   GPSM2 [ EBI - ARRAY_EXPRESS ]   GPSM2 [ SEEK ]   GPSM2 [ MEM ]
Gene Expression Viewer (FireBrowse)GPSM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29899
GTEX Portal (Tissue expression)GPSM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP81274 (Uniprot)
NextProtP81274  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP81274
Splice isoforms : SwissVarP81274 (Swissvar)
PhosPhoSitePlusP81274
Domaine pattern : Prosite (Expaxy)GOLOCO (PS50877)    TPR (PS50005)    TPR_REGION (PS50293)   
Domains : Interpro (EBI)GoLoco_motif    TPR-contain_dom    TPR-like_helical_dom    TPR_repeat   
Domain families : Pfam (Sanger)GoLoco (PF02188)   
Domain families : Pfam (NCBI)pfam02188   
Domain families : Smart (EMBL)GoLoco (SM00390)  TPR (SM00028)  
DMDM Disease mutations29899
Blocks (Seattle)GPSM2
PDB (SRS)3SF4    4WND    4WNE    4WNF    4WNG    5A6C   
PDB (PDBSum)3SF4    4WND    4WNE    4WNF    4WNG    5A6C   
PDB (IMB)3SF4    4WND    4WNE    4WNF    4WNG    5A6C   
PDB (RSDB)3SF4    4WND    4WNE    4WNF    4WNG    5A6C   
Structural Biology KnowledgeBase3SF4    4WND    4WNE    4WNF    4WNG    5A6C   
SCOP (Structural Classification of Proteins)3SF4    4WND    4WNE    4WNF    4WNG    5A6C   
CATH (Classification of proteins structures)3SF4    4WND    4WNE    4WNF    4WNG    5A6C   
SuperfamilyP81274
Human Protein AtlasENSG00000121957
Peptide AtlasP81274
HPRD06609
IPIIPI00642575   IPI00889631   IPI00883886   IPI00893157   IPI00893765   
Protein Interaction databases
DIP (DOE-UCLA)P81274
IntAct (EBI)P81274
FunCoupENSG00000121957
BioGRIDGPSM2
STRING (EMBL)GPSM2
ZODIACGPSM2
Ontologies - Pathways
QuickGOP81274
Ontology : AmiGOestablishment of mitotic spindle orientation  nucleotide binding  G-protein alpha-subunit binding  GDP-dissociation inhibitor activity  protein binding  cytoplasm  cell cortex  mitotic spindle organization  G-protein coupled receptor signaling pathway  identical protein binding  apical part of cell  regulation of catalytic activity  maintenance of centrosome location  lung epithelial cell differentiation  mitotic spindle pole  
Ontology : EGO-EBIestablishment of mitotic spindle orientation  nucleotide binding  G-protein alpha-subunit binding  GDP-dissociation inhibitor activity  protein binding  cytoplasm  cell cortex  mitotic spindle organization  G-protein coupled receptor signaling pathway  identical protein binding  apical part of cell  regulation of catalytic activity  maintenance of centrosome location  lung epithelial cell differentiation  mitotic spindle pole  
NDEx Network
Atlas of Cancer Signalling NetworkGPSM2
Wikipedia pathwaysGPSM2
Orthology - Evolution
OrthoDB29899
GeneTree (enSembl)ENSG00000121957
Phylogenetic Trees/Animal Genes : TreeFamGPSM2
Homologs : HomoloGeneGPSM2
Homology/Alignments : Family Browser (UCSC)GPSM2
Gene fusions - Rearrangements
Fusion: TCGAMTF2 1p22.1 GPSM2 1p13.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerGPSM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPSM2
dbVarGPSM2
ClinVarGPSM2
1000_GenomesGPSM2 
Exome Variant ServerGPSM2
ExAC (Exome Aggregation Consortium)GPSM2 (select the gene name)
Genetic variants : HAPMAP29899
Genomic Variants (DGV)GPSM2 [DGVbeta]
Mutations
ICGC Data PortalGPSM2 
TCGA Data PortalGPSM2 
Broad Tumor PortalGPSM2
OASIS PortalGPSM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPSM2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GPSM2
DgiDB (Drug Gene Interaction Database)GPSM2
DoCM (Curated mutations)GPSM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPSM2 (select a term)
intoGenGPSM2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:109419603-109473044  ENSG00000121957
CONAN: Copy Number AnalysisGPSM2 
Mutations and Diseases : HGMDGPSM2
OMIM604213    609245   
MedgenGPSM2
Genetic Testing Registry GPSM2
NextProtP81274 [Medical]
TSGene29899
GENETestsGPSM2
Huge Navigator GPSM2 [HugePedia]
snp3D : Map Gene to Disease29899
BioCentury BCIQGPSM2
ClinGenGPSM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29899
Chemical/Pharm GKB GenePA134993615
Clinical trialGPSM2
Miscellaneous
canSAR (ICR)GPSM2 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPSM2
EVEXGPSM2
GoPubMedGPSM2
iHOPGPSM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:21:03 CEST 2016

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