Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GPX3 (glutathione peroxidase 3 (plasma))

Identity

Other namesGPx-P
GSHPx-3
GSHPx-P
HGNC (Hugo) GPX3
Location 5q33.1
Location_base_pair Starts at 150380192 and ends at 150388747 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GPX3   4555
Entrez_Gene (NCBI)GPX3  2878  glutathione peroxidase 3 (plasma)
Cards
GeneCards (Weizmann)GPX3
Ensembl (Hinxton)ENSG00000211445 [Gene_View]  GPX3 [Vega]
AceView (NCBI)GPX3
Genatlas (Paris)GPX3
euGene (Indiana)2878
SOURCE (Stanford)NM_002084
Gene Expression (Array Express) ENSG00000211445
Genomic and cartography
GoldenPath (UCSC)GPX3  -  5q33.1   chr5:150380192-150388747 +  5q33.1   [Description]    (hg18-March_2006)
EnsemblGPX3 - 5q33.1 [CytoView]
Mapping of homologs : NCBIGPX3 [Mapview]
OMIM138321   
Gene and transcription
Gene : Genbank (Entrez)AF217787 AK310242 AL036834 BC013218 BC013601
Reference sequence (RefSeq transcript) :SRSNM_002084
Reference transcript : EntrezNM_002084
RefSeq genomic : SRSAC_000048 AC_000137 NC_000005 NT_029289 NW_001838953 NW_922784
RefSeq genomic : EntrezAC_000048 AC_000137 NC_000005 NT_029289 NW_001838953 NW_922784
Consensus coding sequences : CCDS NCBIGPX3
Cluster EST : UnigeneHs.386793 [ SRS ] Hs.386793 [ NCBI ]
Alternative Splicing : Fast-db (Paris)12200
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP22352 (SRS) P22352 (Expasy) P22352 (Uniprot)
With graphics : InterProP22352
Splice isoforms : VarSplice FASTAP22352(VarSplice FASTA)
Domaine pattern : Prosite (SRS)GLUTATHIONE_PEROXID_1 (PS00460)    GLUTATHIONE_PEROXID_2 (PS00763)    GLUTATHIONE_PEROXID_3 (PS51355)   
Domain pattern : Prosite (Expaxy)GLUTATHIONE_PEROXID_1 (PS00460)    GLUTATHIONE_PEROXID_2 (PS00763)    GLUTATHIONE_PEROXID_3 (PS51355)   
Domains : Interpro (SRS)Glutathione_peroxidase    Thioredoxin-like_fold    Thioredoxin_fold   
Domains : Interpro (EBI)Glutathione_peroxidase    Thioredoxin-like_fold    Thioredoxin_fold   
Related proteins : CluSTrP22352
Domain families : Pfam SRSGSHPx (PF00255)   
Domain families : Pfam SangerGSHPx (PF00255)   
Domain families : Pfam NCBIpfam00255   
Blocks (Seattle)P22352
Crystal structure of protein : PDB SRS2R37   
Crystal structure of protein : PDBSum2R37   
Crystal structure of protein : IMB2R37   
Crystal structure of protein : PDB RSDB2R37   
HPRD11750
Protein Interaction databases
DIP (DOE-UCLA)P22352
IntAct (EBI)P22352
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIGPX3
SNP : GeneSNP UtahGPX3
SNP : HGBaseGPX3
Genetic variants : HAPMAPGPX3
Mutations and Diseases : HGMDGPX3
Hereditary diseases : OMIM138321   
Hereditary diseases : GENETests138321   
Diseases : Genetic AssociationGPX3
General knowledge
Homologs : HomoloGeneGPX3
Homology/Alignments : Family Browser UCSCGPX3
Phylogenetic Trees/Animal Genes : TreeFamGPX3
Catalytic activity : Enzyme1.11.1.9 [ Enzyme-Expasy ]   1.11.1.9 [ Enzyme-SRS ]   1.11.1.9 [ IntEnz-EBI ]   1.11.1.9 [ BRENDA ]   1.11.1.9 [ KEGG ]   
Chemical/Protein Interactions : CTD2878
Keywords Ontology : AmiGOglutathione peroxidase activity  extracellular region  extracellular space  soluble fraction  glutathione metabolic process  response to oxidative stress  response to lipid hydroperoxide  transcription factor binding  selenium binding  oxidoreductase activity  hydrogen peroxide catabolic process  glutathione binding  protein homotetramerization  oxidation reduction  
Keywords Ontology : EGO-EBIglutathione peroxidase activity  extracellular region  extracellular space  soluble fraction  glutathione metabolic process  response to oxidative stress  response to lipid hydroperoxide  transcription factor binding  selenium binding  oxidoreductase activity  hydrogen peroxide catabolic process  glutathione binding  protein homotetramerization  oxidation reduction  
Pathways : BIOCARTA
Pathways : KEGGGlutathione metabolismArachidonic acid metabolism
Other databases
Probes
Probes : ImagenesGPX3 Related clones (RZPD - Berlin)
Literature
PubMed40 Pubmed reference(s) in Entrez
PubGeneGPX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:45:34 CET 2010
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.