GPX6 (glutathione peroxidase 6)

2014-08-01  

Identity

HGNC
LOCATION
6p22.1
LOCUSID
ALIAS
GPX5p,GPXP3,GPx-6,GSHPx-6,dJ1186N24,dJ1186N24.1
FUSION GENES

Other Information

Locus ID:

NCBI: 257202
MIM: 607913
HGNC: 4558
Ensembl: ENSG00000198704

Variants:

dbSNP: 257202
ClinVar: 257202
TCGA: ENSG00000198704
COSMIC: GPX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198704ENST00000361902P59796
ENSG00000198704ENST00000474923A0A182DWH6
ENSG00000198704ENST00000612264A0A087X0K3

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Arachidonic acid metabolismKEGGko00590
Glutathione metabolismKEGGhsa00480
Arachidonic acid metabolismKEGGhsa00590
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.20
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

GPX6 (glutathione peroxidase 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54346/gpx6