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GRAMD4 (GRAM domain containing 4)

Identity

Alias_symbol (synonym)KIAA0767
DIP
Other alias
HGNC (Hugo) GRAMD4
LocusID (NCBI) 23151
Atlas_Id 53792
Location 22q13.31  [Link to chromosome band 22q13]
Location_base_pair Starts at 46620386 and ends at 46679785 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GRAMD4 (22q13.31) / GTSE1 (22q13.31)GRAMD4 (22q13.31) / SET (9q34.11)TBC1D22A (22q13.31) / GRAMD4 (22q13.31)
TBC1D22A 22q13.31 / GRAMD4 22q13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  TBC1D22A/GRAMD4 (22q13)

External links

Nomenclature
HGNC (Hugo)GRAMD4   29113
Cards
Entrez_Gene (NCBI)GRAMD4  23151  GRAM domain containing 4
AliasesDIP
GeneCards (Weizmann)GRAMD4
Ensembl hg19 (Hinxton)ENSG00000075240 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000075240 [Gene_View]  ENSG00000075240 [Sequence]  chr22:46620386-46679785 [Contig_View]  GRAMD4 [Vega]
ICGC DataPortalENSG00000075240
TCGA cBioPortalGRAMD4
AceView (NCBI)GRAMD4
Genatlas (Paris)GRAMD4
WikiGenes23151
SOURCE (Princeton)GRAMD4
Genetics Home Reference (NIH)GRAMD4
Genomic and cartography
GoldenPath hg38 (UCSC)GRAMD4  -     chr22:46620386-46679785 +  22q13.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRAMD4  -     22q13.31   [Description]    (hg19-Feb_2009)
GoldenPathGRAMD4 - 22q13.31 [CytoView hg19]  GRAMD4 - 22q13.31 [CytoView hg38]
ImmunoBaseENSG00000075240
Mapping of homologs : NCBIGRAMD4 [Mapview hg19]  GRAMD4 [Mapview hg38]
OMIM613691   
Gene and transcription
Genbank (Entrez)AB018310 AI399959 AL137628 BC011984 BC033170
RefSeq transcript (Entrez)NM_001366660 NM_015124
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRAMD4
Alternative Splicing GalleryENSG00000075240
Gene ExpressionGRAMD4 [ NCBI-GEO ]   GRAMD4 [ EBI - ARRAY_EXPRESS ]   GRAMD4 [ SEEK ]   GRAMD4 [ MEM ]
Gene Expression Viewer (FireBrowse)GRAMD4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23151
GTEX Portal (Tissue expression)GRAMD4
Human Protein AtlasENSG00000075240-GRAMD4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6IC98   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6IC98  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6IC98
Splice isoforms : SwissVarQ6IC98
PhosPhoSitePlusQ6IC98
Domains : Interpro (EBI)GRAM    GRAMDC4    GRAMDC4_PH-GRAM    PH-like_dom_sf   
Domain families : Pfam (Sanger)GRAM (PF02893)   
Domain families : Pfam (NCBI)pfam02893   
Domain families : Smart (EMBL)GRAM (SM00568)  
Conserved Domain (NCBI)GRAMD4
DMDM Disease mutations23151
Blocks (Seattle)GRAMD4
SuperfamilyQ6IC98
Human Protein Atlas [tissue]ENSG00000075240-GRAMD4 [tissue]
Peptide AtlasQ6IC98
HPRD11107
IPIIPI00019690   IPI00878499   IPI00878325   IPI00878812   IPI00878652   
Protein Interaction databases
DIP (DOE-UCLA)Q6IC98
IntAct (EBI)Q6IC98
FunCoupENSG00000075240
BioGRIDGRAMD4
STRING (EMBL)GRAMD4
ZODIACGRAMD4
Ontologies - Pathways
QuickGOQ6IC98
Ontology : AmiGOmolecular_function  mitochondrion  mitochondrion  endoplasmic reticulum membrane  apoptotic process  integral component of membrane  mitochondrial membrane  negative regulation of toll-like receptor 9 signaling pathway  negative regulation of toll-like receptor 9 signaling pathway  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  
Ontology : EGO-EBImolecular_function  mitochondrion  mitochondrion  endoplasmic reticulum membrane  apoptotic process  integral component of membrane  mitochondrial membrane  negative regulation of toll-like receptor 9 signaling pathway  negative regulation of toll-like receptor 9 signaling pathway  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  
NDEx NetworkGRAMD4
Atlas of Cancer Signalling NetworkGRAMD4
Wikipedia pathwaysGRAMD4
Orthology - Evolution
OrthoDB23151
GeneTree (enSembl)ENSG00000075240
Phylogenetic Trees/Animal Genes : TreeFamGRAMD4
HOGENOMQ6IC98
Homologs : HomoloGeneGRAMD4
Homology/Alignments : Family Browser (UCSC)GRAMD4
Gene fusions - Rearrangements
Fusion : MitelmanTBC1D22A/GRAMD4 [22q13.31/22q13.31]  [t(22;22)(q13;q13)]  
Fusion PortalTBC1D22A 22q13.31 GRAMD4 22q13.31 BRCA
Fusion : QuiverGRAMD4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRAMD4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRAMD4
dbVarGRAMD4
ClinVarGRAMD4
1000_GenomesGRAMD4 
Exome Variant ServerGRAMD4
ExAC (Exome Aggregation Consortium)ENSG00000075240
GNOMAD BrowserENSG00000075240
Varsome BrowserGRAMD4
Genetic variants : HAPMAP23151
Genomic Variants (DGV)GRAMD4 [DGVbeta]
DECIPHERGRAMD4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRAMD4 
Mutations
ICGC Data PortalGRAMD4 
TCGA Data PortalGRAMD4 
Broad Tumor PortalGRAMD4
OASIS PortalGRAMD4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRAMD4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGRAMD4
Mutations and Diseases : HGMDGRAMD4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRAMD4
DgiDB (Drug Gene Interaction Database)GRAMD4
DoCM (Curated mutations)GRAMD4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRAMD4 (select a term)
intoGenGRAMD4
Cancer3DGRAMD4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613691   
Orphanet
DisGeNETGRAMD4
MedgenGRAMD4
Genetic Testing Registry GRAMD4
NextProtQ6IC98 [Medical]
TSGene23151
GENETestsGRAMD4
Target ValidationGRAMD4
Huge Navigator GRAMD4 [HugePedia]
snp3D : Map Gene to Disease23151
BioCentury BCIQGRAMD4
ClinGenGRAMD4
Clinical trials, drugs, therapy
Protein Interactions : CTD23151
Pharm GKB GenePA162390212
Clinical trialGRAMD4
Miscellaneous
canSAR (ICR)GRAMD4 (select the gene name)
HarmonizomeGRAMD4
DataMed IndexGRAMD4
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRAMD4
EVEXGRAMD4
GoPubMedGRAMD4
iHOPGRAMD4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Jun 30 20:17:29 CEST 2020
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