Identity
HGNC
LOCATION
Xq25
LOCUSID
ALIAS
GLUR-C,GLUR-K3,GLUR3,GLURC,GluA3,MRX94,MRXSW
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2892
MIM: 305915
HGNC: 4573
Ensembl: ENSG00000125675
Variants:
dbSNP: 2892
ClinVar: 2892
TCGA: ENSG00000125675
COSMIC: GRIA3
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713257 | Selective serotonin reuptake inhibitors | Chemical | ClinicalAnnotation | associated | PD | 23394390 | |
| PA165374639 | suicide | Disease | ClinicalAnnotation | associated | PD | 17898344 | |
| PA447278 | Depression | Disease | ClinicalAnnotation | associated | PD | 17898344 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 23394390 | |
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 17898344 | |
| PA451866 | venlafaxine | Chemical | ClinicalAnnotation | associated | PD | 23394390 | |
| PA452229 | antidepressants | Chemical | ClinicalAnnotation | associated | PD | 23394390 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38038360 | 2024 | Gain-of-function and loss-of-function variants in GRIA3 lead to distinct neurodevelopmental phenotypes. | 1 |
| 38038360 | 2024 | Gain-of-function and loss-of-function variants in GRIA3 lead to distinct neurodevelopmental phenotypes. | 1 |
| 34652536 | 2022 | Acetylation of H3K27 activated lncRNA NEAT1 and promoted hepatic lipid accumulation in non-alcoholic fatty liver disease via regulating miR-212-5p/GRIA3. | 14 |
| 35031858 | 2022 | Amelioration of a neurodevelopmental disorder by carbamazepine in a case having a gain-of-function GRIA3 variant. | 4 |
| 35697757 | 2022 | Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human. | 4 |
| 34652536 | 2022 | Acetylation of H3K27 activated lncRNA NEAT1 and promoted hepatic lipid accumulation in non-alcoholic fatty liver disease via regulating miR-212-5p/GRIA3. | 14 |
| 35031858 | 2022 | Amelioration of a neurodevelopmental disorder by carbamazepine in a case having a gain-of-function GRIA3 variant. | 4 |
| 35697757 | 2022 | Dysfunction of AMPA receptor GluA3 is associated with aggressive behavior in human. | 4 |
| 34161333 | 2021 | X-linked neonatal-onset epileptic encephalopathy associated with a gain-of-function variant p.R660T in GRIA3. | 8 |
| 34161333 | 2021 | X-linked neonatal-onset epileptic encephalopathy associated with a gain-of-function variant p.R660T in GRIA3. | 8 |
| 32369665 | 2020 | The GRIA3 c.2477G > A Variant Causes an Exaggerated Startle Reflex, Chorea, and Multifocal Myoclonus. | 7 |
| 33269432 | 2020 | TRAILR1 (rs20576) and GRIA3 (rs12557782) are not associated with interferon-β response in multiple sclerosis patients. | 0 |
| 32369665 | 2020 | The GRIA3 c.2477G > A Variant Causes an Exaggerated Startle Reflex, Chorea, and Multifocal Myoclonus. | 7 |
| 33269432 | 2020 | TRAILR1 (rs20576) and GRIA3 (rs12557782) are not associated with interferon-β response in multiple sclerosis patients. | 0 |
| 31498117 | 2019 | MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer. | 27 |
Citation
Dessen P
GRIA3 (glutamate ionotropic receptor AMPA type subunit 3)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46508/gria3
