GRIA3 (glutamate ionotropic receptor AMPA type subunit 3)

2007-02-01 Affiliation

Identity

HGNC

GRIA3

LOCATION

Xq25

LOCUSID

2892

ALIAS

GLUR-C,GLUR-K3,GLUR3,GLURC,GluA3,MRX94,MRXSW

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2892
MIM: 305915
HGNC: 4573
Ensembl: ENSG00000125675

Variants:

dbSNP: 2892
ClinVar: 2892
TCGA: ENSG00000125675
COSMIC: GRIA3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000125675	ENST00000541091	P42263
ENSG00000125675	ENST00000611689	Q5XKG2
ENSG00000125675	ENST00000616590	Q5XKG2
ENSG00000125675	ENST00000620443	P42263
ENSG00000125675	ENST00000620581	A0A087WYJ6
ENSG00000125675	ENST00000622768	P42263

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Long-term depression	KEGG	ko04730
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Long-term depression	KEGG	hsa04730
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Dopaminergic synapse	KEGG	ko04728
Dopaminergic synapse	KEGG	hsa04728
Transcriptional misregulation in cancer	KEGG	ko05202
Transcriptional misregulation in cancer	KEGG	hsa05202
Retrograde endocannabinoid signaling	KEGG	hsa04723
Retrograde endocannabinoid signaling	KEGG	ko04723
Amphetamine addiction	KEGG	hsa05031
Amphetamine addiction	KEGG	ko05031
Nicotine addiction	KEGG	hsa05033
Nicotine addiction	KEGG	ko05033
Circadian entrainment	KEGG	hsa04713
Circadian entrainment	KEGG	ko04713
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity	REACTOME	R-HSA-399721
Trafficking of AMPA receptors	REACTOME	R-HSA-399719
Trafficking of GluR2-containing AMPA receptors	REACTOME	R-HSA-416993
Activation of AMPA receptors	REACTOME	R-HSA-399710
Activation of NMDA receptor upon glutamate binding and postsynaptic events	REACTOME	R-HSA-442755
Unblocking of NMDA receptor, glutamate binding and activation	REACTOME	R-HSA-438066
SALM protein interactions at the synapses	REACTOME	R-HSA-8849932
Protein-protein interactions at synapses	REACTOME	R-HSA-6794362

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA164713257	Selective serotonin reuptake inhibitors	Chemical	ClinicalAnnotation	associated	PD	23394390
PA165374639	suicide	Disease	ClinicalAnnotation	associated	PD	17898344
PA447278	Depression	Disease	ClinicalAnnotation	associated	PD	17898344
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	23394390
PA449015	citalopram	Chemical	ClinicalAnnotation	associated	PD	17898344
PA451866	venlafaxine	Chemical	ClinicalAnnotation	associated	PD	23394390
PA452229	antidepressants	Chemical	ClinicalAnnotation	associated	PD	23394390

References

Pubmed ID	Year	Title	Citations
19736351	2009	Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.	151
19933774	2010	Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain?	47
19156168	2009	Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.	46
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
12682273	2003	Human T cells express a functional ionotropic glutamate receptor GluR3, and glutamate by itself triggers integrin-mediated adhesion to laminin and fibronectin and chemotactic migration.	30
17989220	2007	Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans.	30
25433904	2015	Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.	29
19548263	2010	A population-based association study of candidate genes for depression and sleep disturbance.	26
19295509	2009	Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients.	22
28629431	2017	MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway.	22

Citation

Dessen P

GRIA3 (glutamate ionotropic receptor AMPA type subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46508/gria3