GRIA4 (glutamate ionotropic receptor AMPA type subunit 4)

2014-11-01  

Identity

HGNC
LOCATION
11q22.3
LOCUSID
ALIAS
GLUR4,GLUR4C,GLURD,GluA4,NEDSGA
FUSION GENES

Other Information

Locus ID:

NCBI: 2893
MIM: 138246
HGNC: 4574
Ensembl: ENSG00000152578

Variants:

dbSNP: 2893
ClinVar: 2893
TCGA: ENSG00000152578
COSMIC: GRIA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152578ENST00000282499P48058
ENSG00000152578ENST00000393125P48058
ENSG00000152578ENST00000393127G3V164
ENSG00000152578ENST00000428631P48058
ENSG00000152578ENST00000525187G3V164
ENSG00000152578ENST00000525921E9PJZ5
ENSG00000152578ENST00000525942H0YDL4
ENSG00000152578ENST00000527177E9PJZ5
ENSG00000152578ENST00000527669E9PR13
ENSG00000152578ENST00000530497P48058
ENSG00000152578ENST00000531011E9PQY1
ENSG00000152578ENST00000531986E9PJZ5

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Trafficking of GluR2-containing AMPA receptorsREACTOMER-HSA-416993
Activation of AMPA receptorsREACTOMER-HSA-399710
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsREACTOMER-HSA-442755
Unblocking of NMDA receptor, glutamate binding and activationREACTOMER-HSA-438066
SALM protein interactions at the synapsesREACTOMER-HSA-8849932
Protein-protein interactions at synapsesREACTOMER-HSA-6794362

References

Pubmed IDYearTitleCitations
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
185210902009Association of the NPAS3 gene and five other loci with response to the antipsychotic iloperidone identified in a whole genome association study.44
249620262014Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4.39
123939052002Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels lacking the N-terminal domain.35
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
254339042015Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.29
161908732005Phosphorylation-dependent interactions of alpha-Actinin-1/IQGAP1 with the AMPA receptor subunit GluR4.16
267441922016Superactivation of AMPA receptors by auxiliary proteins.16
172337592007PKC anchoring to GluR4 AMPA receptor subunit modulates PKC-driven receptor phosphorylation and surface expression.15
195734792009Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia.12

Citation

Dessen P

GRIA4 (glutamate ionotropic receptor AMPA type subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64035/gria4