Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2895
MIM: 602368
HGNC: 4576
Ensembl: ENSG00000152208
Variants:
dbSNP: 2895
ClinVar: 2895
TCGA: ENSG00000152208
COSMIC: GRID2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Neuroactive ligand-receptor interaction | KEGG | ko04080 |
| Long-term depression | KEGG | ko04730 |
| Neuroactive ligand-receptor interaction | KEGG | hsa04080 |
| Long-term depression | KEGG | hsa04730 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | 26905411 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37944084 | 2024 | Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants. | 1 |
| 37944084 | 2024 | Clinical features, functional consequences, and rescue pharmacology of missense GRID1 and GRID2 human variants. | 1 |
| 35159210 | 2022 | Neurodevelopmental Syndrome with Intellectual Disability, Speech Impairment, and Quadrupedia Is Associated with Glutamate Receptor Delta 2 Gene Defect. | 3 |
| 35159210 | 2022 | Neurodevelopmental Syndrome with Intellectual Disability, Speech Impairment, and Quadrupedia Is Associated with Glutamate Receptor Delta 2 Gene Defect. | 3 |
| 32065002 | 2021 | Association of Gene Variations in Ionotropic Glutamate Receptor and Attention-Deficit/Hyperactivity Disorder in the Chinese Population: A Two-Stage Case-Control Study. | 6 |
| 32170608 | 2021 | Autosomal recessive spinocerebellar ataxia 18 caused by homozygous exon 14 duplication in GRID2 and review of the literature. | 6 |
| 32065002 | 2021 | Association of Gene Variations in Ionotropic Glutamate Receptor and Attention-Deficit/Hyperactivity Disorder in the Chinese Population: A Two-Stage Case-Control Study. | 6 |
| 32170608 | 2021 | Autosomal recessive spinocerebellar ataxia 18 caused by homozygous exon 14 duplication in GRID2 and review of the literature. | 6 |
| 29207948 | 2017 | Homozygous GRID2 missense mutation predicts a shift in the D-serine binding domain of GluD2 in a case with generalized brain atrophy and unusual clinical features. | 13 |
| 29207948 | 2017 | Homozygous GRID2 missense mutation predicts a shift in the D-serine binding domain of GluD2 in a case with generalized brain atrophy and unusual clinical features. | 13 |
| 26905411 | 2016 | Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes. | 23 |
| 27019035 | 2016 | Potential of GRID2 receptor gene for preventing TNF-induced neurodegeneration in autism. | 9 |
| 26905411 | 2016 | Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes. | 23 |
| 27019035 | 2016 | Potential of GRID2 receptor gene for preventing TNF-induced neurodegeneration in autism. | 9 |
| 25122145 | 2015 | Early-onset autosomal recessive cerebellar ataxia associated with retinal dystrophy: new human hotfoot phenotype caused by homozygous GRID2 deletion. | 23 |
Citation
Dessen P
GRID2 (glutamate ionotropic receptor delta type subunit 2)
Atlas Genet Cytogenet Oncol Haematol. 2003-05-01
Online version: http://atlasgeneticsoncology.org/gene/40753/grid2
