Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GRIK2 (glutamate ionotropic receptor kainate type subunit 2)

Identity

Alias_namesGLUR6
glutamate receptor, ionotropic, kainate 2
Alias_symbol (synonym)GluK2
MRT6
Other aliasEAA4
GLR6
GLUK6
HGNC (Hugo) GRIK2
LocusID (NCBI) 2898
Atlas_Id 57393
Location 6q16.3  [Link to chromosome band 6q16]
Location_base_pair Starts at 101398985 and ends at 102070083 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASCC3 (6q16.3) / GRIK2 (6q16.3)BCAS3 (17q23.2) / GRIK2 (6q16.3)GRIK2 (6q16.3) / CDKAL1 (6p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(6;6)(p22;q16) GRIK2/CDKAL1
ASCC3/GRIK2 (6q16)
t(6;6)(q16;q21) GRIK2/SOBP
t(6;6)(q16;q22) TRMT11/GRIK2
t(6;17)(q16;q23) BCAS3/GRIK2

External links

Nomenclature
HGNC (Hugo)GRIK2   4580
Cards
Entrez_Gene (NCBI)GRIK2  2898  glutamate ionotropic receptor kainate type subunit 2
AliasesEAA4; GLR6; GLUK6; GLUR6; 
GluK2; MRT6
GeneCards (Weizmann)GRIK2
Ensembl hg19 (Hinxton)ENSG00000164418 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164418 [Gene_View]  ENSG00000164418 [Sequence]  chr6:101398985-102070083 [Contig_View]  GRIK2 [Vega]
ICGC DataPortalENSG00000164418
TCGA cBioPortalGRIK2
AceView (NCBI)GRIK2
Genatlas (Paris)GRIK2
WikiGenes2898
SOURCE (Princeton)GRIK2
Genetics Home Reference (NIH)GRIK2
Genomic and cartography
GoldenPath hg38 (UCSC)GRIK2  -     chr6:101398985-102070083 +  6q16.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRIK2  -     6q16.3   [Description]    (hg19-Feb_2009)
GoldenPathGRIK2 - 6q16.3 [CytoView hg19]  GRIK2 - 6q16.3 [CytoView hg38]
ImmunoBaseENSG00000164418
Mapping of homologs : NCBIGRIK2 [Mapview hg19]  GRIK2 [Mapview hg38]
OMIM138244   611092   
Gene and transcription
Genbank (Entrez)AI087397 AJ252246 AJ301608 AJ301609 AJ301610
RefSeq transcript (Entrez)NM_001166247 NM_021956 NM_175768
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRIK2
Cluster EST : UnigeneHs.98262 [ NCBI ]
CGAP (NCI)Hs.98262
Alternative Splicing GalleryENSG00000164418
Gene ExpressionGRIK2 [ NCBI-GEO ]   GRIK2 [ EBI - ARRAY_EXPRESS ]   GRIK2 [ SEEK ]   GRIK2 [ MEM ]
Gene Expression Viewer (FireBrowse)GRIK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2898
GTEX Portal (Tissue expression)GRIK2
Human Protein AtlasENSG00000164418-GRIK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13002   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13002  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13002
Splice isoforms : SwissVarQ13002
PhosPhoSitePlusQ13002
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRIK2
DMDM Disease mutations2898
Blocks (Seattle)GRIK2
PDB (RSDB)3QXM    5CMM   
PDB Europe3QXM    5CMM   
PDB (PDBSum)3QXM    5CMM   
PDB (IMB)3QXM    5CMM   
Structural Biology KnowledgeBase3QXM    5CMM   
SCOP (Structural Classification of Proteins)3QXM    5CMM   
CATH (Classification of proteins structures)3QXM    5CMM   
SuperfamilyQ13002
Human Protein Atlas [tissue]ENSG00000164418-GRIK2 [tissue]
Peptide AtlasQ13002
IPIIPI00011396   IPI00396613   IPI00815931   IPI00746275   IPI00642591   IPI00969582   IPI01012035   IPI00643111   IPI01012339   
Protein Interaction databases
DIP (DOE-UCLA)Q13002
IntAct (EBI)Q13002
FunCoupENSG00000164418
BioGRIDGRIK2
STRING (EMBL)GRIK2
ZODIACGRIK2
Ontologies - Pathways
QuickGOQ13002
Ontology : AmiGObehavioral fear response  extracellularly glutamate-gated ion channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  glutamate receptor signaling pathway  chemical synaptic transmission  glutamate receptor activity  postsynaptic density  kainate selective glutamate receptor activity  kainate selective glutamate receptor activity  neuronal action potential  cell junction  PDZ domain binding  ubiquitin conjugating enzyme binding  ubiquitin protein ligase binding  dendrite cytoplasm  kainate selective glutamate receptor complex  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  presynaptic membrane  protein homodimerization activity  receptor clustering  terminal bouton  perikaryon  negative regulation of neuron apoptotic process  positive regulation of neuron apoptotic process  postsynaptic membrane  regulation of JNK cascade  regulation of long-term neuronal synaptic plasticity  regulation of short-term neuronal synaptic plasticity  modulation of chemical synaptic transmission  modulation of chemical synaptic transmission  positive regulation of synaptic transmission  neuron apoptotic process  negative regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  inhibitory postsynaptic potential  hippocampal mossy fiber to CA3 synapse  glutamatergic synapse  regulation of presynaptic membrane potential  ligand-gated ion channel activity involved in regulation of presynaptic membrane potential  transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential  
Ontology : EGO-EBIbehavioral fear response  extracellularly glutamate-gated ion channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  cellular calcium ion homeostasis  glutamate receptor signaling pathway  chemical synaptic transmission  glutamate receptor activity  postsynaptic density  kainate selective glutamate receptor activity  kainate selective glutamate receptor activity  neuronal action potential  cell junction  PDZ domain binding  ubiquitin conjugating enzyme binding  ubiquitin protein ligase binding  dendrite cytoplasm  kainate selective glutamate receptor complex  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  presynaptic membrane  protein homodimerization activity  receptor clustering  terminal bouton  perikaryon  negative regulation of neuron apoptotic process  positive regulation of neuron apoptotic process  postsynaptic membrane  regulation of JNK cascade  regulation of long-term neuronal synaptic plasticity  regulation of short-term neuronal synaptic plasticity  modulation of chemical synaptic transmission  modulation of chemical synaptic transmission  positive regulation of synaptic transmission  neuron apoptotic process  negative regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  inhibitory postsynaptic potential  hippocampal mossy fiber to CA3 synapse  glutamatergic synapse  regulation of presynaptic membrane potential  ligand-gated ion channel activity involved in regulation of presynaptic membrane potential  transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential  
Pathways : KEGGNeuroactive ligand-receptor interaction    Glutamatergic synapse   
NDEx NetworkGRIK2
Atlas of Cancer Signalling NetworkGRIK2
Wikipedia pathwaysGRIK2
Orthology - Evolution
OrthoDB2898
GeneTree (enSembl)ENSG00000164418
Phylogenetic Trees/Animal Genes : TreeFamGRIK2
HOGENOMQ13002
Homologs : HomoloGeneGRIK2
Homology/Alignments : Family Browser (UCSC)GRIK2
Gene fusions - Rearrangements
Fusion : QuiverGRIK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIK2
dbVarGRIK2
ClinVarGRIK2
1000_GenomesGRIK2 
Exome Variant ServerGRIK2
ExAC (Exome Aggregation Consortium)ENSG00000164418
GNOMAD BrowserENSG00000164418
Varsome BrowserGRIK2
Genetic variants : HAPMAP2898
Genomic Variants (DGV)GRIK2 [DGVbeta]
DECIPHERGRIK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRIK2 
Mutations
ICGC Data PortalGRIK2 
TCGA Data PortalGRIK2 
Broad Tumor PortalGRIK2
OASIS PortalGRIK2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIK2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGRIK2
Mutations and Diseases : HGMDGRIK2
BioMutasearch GRIK2
DgiDB (Drug Gene Interaction Database)GRIK2
DoCM (Curated mutations)GRIK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIK2 (select a term)
intoGenGRIK2
Cancer3DGRIK2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138244    611092   
Orphanet
DisGeNETGRIK2
MedgenGRIK2
Genetic Testing Registry GRIK2
NextProtQ13002 [Medical]
TSGene2898
GENETestsGRIK2
Target ValidationGRIK2
Huge Navigator GRIK2 [HugePedia]
snp3D : Map Gene to Disease2898
BioCentury BCIQGRIK2
ClinGenGRIK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2898
Chemical/Pharm GKB GenePA164741600
Clinical trialGRIK2
Miscellaneous
canSAR (ICR)GRIK2 (select the gene name)
DataMed IndexGRIK2
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIK2
EVEXGRIK2
GoPubMedGRIK2
iHOPGRIK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 17:45:42 CET 2019
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