GRIK4 (glutamate ionotropic receptor kainate type subunit 4)

2014-11-01 Affiliation

Identity

HGNC

GRIK4

LOCATION

11q23.3

LOCUSID

2900

ALIAS

EAA1,GRIK,GluK4,KA1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2900
MIM: 600282
HGNC: 4582
Ensembl: ENSG00000149403

Variants:

dbSNP: 2900
ClinVar: 2900
TCGA: ENSG00000149403
COSMIC: GRIK4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000149403	ENST00000438375	Q16099
ENSG00000149403	ENST00000527524	Q16099
ENSG00000149403	ENST00000638419	Q16099

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Activation of Kainate Receptors upon glutamate binding	REACTOME	R-HSA-451326
Ionotropic activity of Kainate Receptors	REACTOME	R-HSA-451306
Activation of Ca-permeable Kainate Receptor	REACTOME	R-HSA-451308

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA447207	Depressive Disorder	Disease	ClinicalAnnotation	associated	PD	17671280, 19924111, 23394390
PA447278	Depression	Disease	ClinicalAnnotation	associated	PD	17671280, 23394390
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	17671280, 23394390
PA449841	haloperidol	Chemical	MultilinkAnnotation	associated		27023437
PA452229	antidepressants	Chemical	ClinicalAnnotation	associated	PD	17671280, 19924111, 23394390

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
20201926	2010	Human variation in alcohol response is influenced by variation in neuronal signaling genes.	45
19924111	2010	Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment.	39
19924111	2010	Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatment.	39
16819533	2006	Cytogenetic and genetic evidence supports a role for the kainate-type glutamate receptor gene, GRIK4, in schizophrenia and bipolar disorder.	38
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
18824690	2008	A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder.	24
18824690	2008	A common variant in the 3'UTR of the GRIK4 glutamate receptor gene affects transcript abundance and protects against bipolar disorder.	24
20110084	2010	Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.	15
22052594	2012	GRIK4/KA1 protein expression in human brain and correlation with bipolar disorder risk variant status.	12

Citation

Dessen P

GRIK4 (glutamate ionotropic receptor kainate type subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64044/grik4