GRIK5 (glutamate ionotropic receptor kainate type subunit 5)

2016-10-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
EAA2,GRIK2,GluK5,KA2
FUSION GENES

Other Information

Locus ID:

NCBI: 2901
MIM: 600283
HGNC: 4583
Ensembl: ENSG00000105737

Variants:

dbSNP: 2901
ClinVar: 2901
TCGA: ENSG00000105737
COSMIC: GRIK5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105737ENST00000262895Q16478
ENSG00000105737ENST00000301218Q16478
ENSG00000105737ENST00000593562Q16478
ENSG00000105737ENST00000594528M0QXF6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of Kainate Receptors upon glutamate bindingREACTOMER-HSA-451326
Ionotropic activity of Kainate ReceptorsREACTOMER-HSA-451306
Activation of Ca-permeable Kainate ReceptorREACTOMER-HSA-451308

References

Pubmed IDYearTitleCitations
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
232880402013CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors.16
145116402003Trafficking and surface expression of the glutamate receptor subunit, KA2.12
182471292008Human herpesvirus 6 (HHV-6) induces dysregulation of glutamate uptake and transporter expression in astrocytes.10
163252632006Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia.5
191251032009Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia.4
308275002019GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish.3
152549512004Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene.1
289000782017[Polymorphic Variants of Glutamate Receptor (GRIK5, GRIN2B) and Serotonin Receptor (HTR2A) Genes Are Associated with Chronic Obstructive Pulmonary Disease].0
303398232019A novel function for the ER retention signals in the C-terminus of kainate receptor subunit, GluK5.0

Citation

Dessen P

GRIK5 (glutamate ionotropic receptor kainate type subunit 5)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56078/grik5