GRIN3B (glutamate ionotropic receptor NMDA type subunit 3B)

2014-11-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
GluN3B,NR3B

Other Information

Locus ID:

NCBI: 116444
MIM: 606651
HGNC: 16768
Ensembl: ENSG00000116032

Variants:

dbSNP: 116444
ClinVar: 116444
TCGA: ENSG00000116032
COSMIC: GRIN3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116032ENST00000234389O60391

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033
AlcoholismKEGGhsa05034
AlcoholismKEGGko05034
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024

References

Pubmed IDYearTitleCitations
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
203989082010Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.32
157221822005Cloning and expression of the human NMDA receptor subunit NR3B in the adult human hippocampus.9
176871152008Motoneuron-specific NR3B gene: no association with ALS and evidence for a common null allele.8
200161822009Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease.8
200161822009Genetic variation in N-methyl-D-aspartate receptor subunit NR3A but not NR3B influences susceptibility to Alzheimer's disease.8
257683062015A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia.7
248141392014A recently-discovered NMDA receptor gene, GRIN3B, is associated with duration mismatch negativity.6
201533132010Expression of NR3B but not NR2D subunit of NMDA receptor in human blood lymphocytes can serve as a suitable peripheral marker for opioid addiction studies.4
281326602017GRIN3B missense mutation as an inherited risk factor for schizophrenia: whole-exome sequencing in a family with a familiar history of psychotic disorders.4

Citation

Dessen P

GRIN3B (glutamate ionotropic receptor NMDA type subunit 3B)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64048/grin3b