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GRIN3B (glutamate ionotropic receptor NMDA type subunit 3B)

Identity

Alias_namesglutamate receptor, ionotropic, N-methyl-D-aspartate 3B
Alias_symbol (synonym)GluN3B
Other aliasNR3B
HGNC (Hugo) GRIN3B
LocusID (NCBI) 116444
Atlas_Id 64048
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 1000419 and ends at 1009732 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GRIN3B   16768
Cards
Entrez_Gene (NCBI)GRIN3B  116444  glutamate ionotropic receptor NMDA type subunit 3B
AliasesGluN3B; NR3B
GeneCards (Weizmann)GRIN3B
Ensembl hg19 (Hinxton)ENSG00000116032 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000116032 [Gene_View]  ENSG00000116032 [Sequence]  chr19:1000419-1009732 [Contig_View]  GRIN3B [Vega]
ICGC DataPortalENSG00000116032
TCGA cBioPortalGRIN3B
AceView (NCBI)GRIN3B
Genatlas (Paris)GRIN3B
WikiGenes116444
SOURCE (Princeton)GRIN3B
Genetics Home Reference (NIH)GRIN3B
Genomic and cartography
GoldenPath hg38 (UCSC)GRIN3B  -     chr19:1000419-1009732 +  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRIN3B  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathGRIN3B - 19p13.3 [CytoView hg19]  GRIN3B - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000116032
genome Data Viewer NCBIGRIN3B [Mapview hg19]  
OMIM606651   
Gene and transcription
Genbank (Entrez)AY507106 AY507107 BK000070 BK004079 BM977634
RefSeq transcript (Entrez)NM_138690
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRIN3B
Alternative Splicing GalleryENSG00000116032
Gene ExpressionGRIN3B [ NCBI-GEO ]   GRIN3B [ EBI - ARRAY_EXPRESS ]   GRIN3B [ SEEK ]   GRIN3B [ MEM ]
Gene Expression Viewer (FireBrowse)GRIN3B [ Firebrowse - Broad ]
GenevisibleExpression of GRIN3B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)116444
GTEX Portal (Tissue expression)GRIN3B
Human Protein AtlasENSG00000116032-GRIN3B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60391   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60391  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60391
Splice isoforms : SwissVarO60391
PhosPhoSitePlusO60391
Domains : Interpro (EBI)Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    Peripla_BP_I   
Domain families : Pfam (Sanger)Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)   
Domain families : Pfam (NCBI)pfam00060    pfam10613   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRIN3B
DMDM Disease mutations116444
Blocks (Seattle)GRIN3B
SuperfamilyO60391
Human Protein Atlas [tissue]ENSG00000116032-GRIN3B [tissue]
Peptide AtlasO60391
IPIIPI00297677   
Protein Interaction databases
DIP (DOE-UCLA)O60391
IntAct (EBI)O60391
FunCoupENSG00000116032
BioGRIDGRIN3B
STRING (EMBL)GRIN3B
ZODIACGRIN3B
Ontologies - Pathways
QuickGOO60391
Ontology : AmiGOionotropic glutamate receptor activity  cation channel activity  calcium channel activity  plasma membrane  glutamate receptor activity  glycine binding  NMDA selective glutamate receptor complex  NMDA selective glutamate receptor complex  cell junction  neurotransmitter receptor activity  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  neurotransmitter binding  neuronal cell body  postsynaptic membrane  modulation of chemical synaptic transmission  protein insertion into membrane  regulation of calcium ion transport  regulation of postsynaptic membrane potential  calcium ion transmembrane transport  postsynaptic density membrane  transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential  
Ontology : EGO-EBIionotropic glutamate receptor activity  cation channel activity  calcium channel activity  plasma membrane  glutamate receptor activity  glycine binding  NMDA selective glutamate receptor complex  NMDA selective glutamate receptor complex  cell junction  neurotransmitter receptor activity  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  neurotransmitter binding  neuronal cell body  postsynaptic membrane  modulation of chemical synaptic transmission  protein insertion into membrane  regulation of calcium ion transport  regulation of postsynaptic membrane potential  calcium ion transmembrane transport  postsynaptic density membrane  transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkGRIN3B
Atlas of Cancer Signalling NetworkGRIN3B
Wikipedia pathwaysGRIN3B
Orthology - Evolution
OrthoDB116444
GeneTree (enSembl)ENSG00000116032
Phylogenetic Trees/Animal Genes : TreeFamGRIN3B
HOGENOMO60391
Homologs : HomoloGeneGRIN3B
Homology/Alignments : Family Browser (UCSC)GRIN3B
Gene fusions - Rearrangements
Fusion : QuiverGRIN3B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIN3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIN3B
dbVarGRIN3B
ClinVarGRIN3B
1000_GenomesGRIN3B 
Exome Variant ServerGRIN3B
GNOMAD BrowserENSG00000116032
Varsome BrowserGRIN3B
Genetic variants : HAPMAP116444
Genomic Variants (DGV)GRIN3B [DGVbeta]
DECIPHERGRIN3B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRIN3B 
Mutations
ICGC Data PortalGRIN3B 
TCGA Data PortalGRIN3B 
Broad Tumor PortalGRIN3B
OASIS PortalGRIN3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIN3B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGRIN3B
Mutations and Diseases : HGMDGRIN3B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIN3B
DgiDB (Drug Gene Interaction Database)GRIN3B
DoCM (Curated mutations)GRIN3B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIN3B (select a term)
intoGenGRIN3B
Cancer3DGRIN3B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606651   
Orphanet
DisGeNETGRIN3B
MedgenGRIN3B
Genetic Testing Registry GRIN3B
NextProtO60391 [Medical]
TSGene116444
GENETestsGRIN3B
Target ValidationGRIN3B
Huge Navigator GRIN3B [HugePedia]
snp3D : Map Gene to Disease116444
BioCentury BCIQGRIN3B
ClinGenGRIN3B
Clinical trials, drugs, therapy
Protein Interactions : CTD116444
Pharm GKB GenePA28984
Clinical trialGRIN3B
Miscellaneous
canSAR (ICR)GRIN3B (select the gene name)
HarmonizomeGRIN3B
DataMed IndexGRIN3B
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIN3B
EVEXGRIN3B
GoPubMedGRIN3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Fri Jul 10 20:04:54 CEST 2020
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