GRK4 (G protein-coupled receptor kinase 4)

2006-10-01  

Identity

HGNC
GRK4
LOCATION
4p16.3
LOCUSID
2868
ALIAS
GPRK2L,GPRK4,GRK4a,IT11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2868
MIM: 137026
HGNC: 4543
Ensembl: ENSG00000125388

Variants:

dbSNP: 2868
ClinVar: 2868
TCGA: ENSG00000125388
COSMIC: GRK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125388ENST00000345167P32298
ENSG00000125388ENST00000398051P32298
ENSG00000125388ENST00000398052P32298
ENSG00000125388ENST00000503518D6REW5
ENSG00000125388ENST00000504933P32298

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
The phototransduction cascadeREACTOMER-HSA-2514856
Inactivation, recovery and regulation of the phototransduction cascadeREACTOMER-HSA-2514859

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166152848hypertensive nephrosclerosisDiseaseClinicalAnnotationassociatedPD
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD22949529
PA444552HypertensionDiseaseClinicalAnnotationassociatedPD22949529
PA444682Kidney DiseasesDiseaseClinicalAnnotationassociatedPD
PA445086NephrosclerosisDiseaseClinicalAnnotationassociatedPD
PA448499atenololChemicalClinicalAnnotationassociatedPD22949529
PA450480metoprololChemicalClinicalAnnotationassociatedPD
PA451868verapamilChemicalClinicalAnnotationassociatedPD22949529

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
201538242010Dopamine and G protein-coupled receptor kinase 4 in the kidney: role in blood pressure regulation.43
166361982006Association study with 33 single-nucleotide polymorphisms in 11 candidate genes for hypertension in Chinese.39
128814162003Phosphorylation-independent desensitization of GABA(B) receptor by GRK4.36
150972322004Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension.35
150972322004Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension.35
195208682009G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor.34
124464682002Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers.31
121648612002Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4.30
163389882006The D1 dopamine receptor is constitutively phosphorylated by G protein-coupled receptor kinase 4.28

Citation

Dessen P

GRK4 (G protein-coupled receptor kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43301/grk4