GRK6 (G protein-coupled receptor kinase 6)

2003-11-01  

Identity

HGNC
LOCATION
5q35.3
LOCUSID
ALIAS
GPRK6

Other Information

Locus ID:

NCBI: 2870
MIM: 600869
HGNC: 4545
Ensembl: ENSG00000198055

Variants:

dbSNP: 2870
ClinVar: 2870
TCGA: ENSG00000198055
COSMIC: GRK6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198055ENST00000355472P43250
ENSG00000198055ENST00000355958P43250
ENSG00000198055ENST00000393576F8W9W2
ENSG00000198055ENST00000502598D6R9V4
ENSG00000198055ENST00000506296D6RHC7
ENSG00000198055ENST00000507633D6RHX8
ENSG00000198055ENST00000508705H0Y967
ENSG00000198055ENST00000511244D6RDA3
ENSG00000198055ENST00000512684D6RC88
ENSG00000198055ENST00000528793P43250

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
166138602006The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs.45
199960892010Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6.43
154988322005Regulation of corticotropin-releasing hormone receptor type 1alpha signaling: structural determinants for G protein-coupled receptor kinase-mediated phosphorylation and agonist-mediated desensitization.31
200386102010Role for the regulator of G-protein signaling homology domain of G protein-coupled receptor kinases 5 and 6 in beta 2-adrenergic receptor and rhodopsin phosphorylation.31
204680642010Association study of 182 candidate genes in anorexia nervosa.30
199565692009Impaired recruitment of Grk6 and beta-Arrestin 2 causes delayed internalization and desensitization of a WHIM syndrome-associated CXCR4 mutant receptor.28
272329752017c-Src, Insulin-Like Growth Factor I Receptor, G-Protein-Coupled Receptor Kinases and Focal Adhesion Kinase are Enriched Into Prostate Cancer Cell Exosomes.25
198015522009G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.23
175380172007Plasma membrane and nuclear localization of G protein coupled receptor kinase 6A.22

Citation

Dessen P

GRK6 (G protein-coupled receptor kinase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40756/grk6