GRK6 (G protein-coupled receptor kinase 6)

2003-11-01  

Identity

HGNC
LOCATION
5q35.3
LOCUSID
ALIAS
GPRK6

Other Information

Locus ID:

NCBI: 2870
MIM: 600869
HGNC: 4545
Ensembl: ENSG00000198055

Variants:

dbSNP: 2870
ClinVar: 2870
TCGA: ENSG00000198055
COSMIC: GRK6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198055ENST00000355472P43250
ENSG00000198055ENST00000355958P43250
ENSG00000198055ENST00000393576F8W9W2
ENSG00000198055ENST00000502598D6R9V4
ENSG00000198055ENST00000506296D6RHC7
ENSG00000198055ENST00000507633D6RHX8
ENSG00000198055ENST00000508705H0Y967
ENSG00000198055ENST00000511244D6RDA3
ENSG00000198055ENST00000512684D6RC88
ENSG00000198055ENST00000528793P43250

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
362610312023M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6.4
362610312023M2 macrophages-derived exosomal miR-3917 promotes the progression of lung cancer via targeting GRK6.4
365555212022The Role of G Protein-Coupled Receptor Kinase 6 Regulation in Inflammation and Pain.3
365555212022The Role of G Protein-Coupled Receptor Kinase 6 Regulation in Inflammation and Pain.3
336004972021Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site.2
336391632021Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport.8
336004972021Characterization of the G protein-coupled receptor kinase 6 promoter reveals a functional CREB binding site.2
336391632021Multisite NHERF1 phosphorylation controls GRK6A regulation of hormone-sensitive phosphate transport.8
323437092020S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.8
323437092020S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson's disease.8
309845362019Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPα, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells.7
312279762019MiR-19b-3p attenuates IL-1β induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6.19
309845362019Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPα, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells.7
312279762019MiR-19b-3p attenuates IL-1β induced extracellular matrix degradation and inflammatory injury in chondrocytes by targeting GRK6.19
298051562018Overexpression of G Protein-Coupled Receptor Kinase 6 (GRK6) Is Associated with Progression and Poor Prognosis of Papillary Thyroid Carcinoma.3

Citation

Dessen P

GRK6 (G protein-coupled receptor kinase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/40756/grk6