GRM2 (glutamate metabotropic receptor 2)

2016-10-01  

Identity

HGNC
LOCATION
3p21.2
LOCUSID
ALIAS
GLUR2,GPRC1B,MGLUR2,mGlu2

Other Information

Locus ID:

NCBI: 2912
MIM: 604099
HGNC: 4594
Ensembl: ENSG00000164082

Variants:

dbSNP: 2912
ClinVar: 2912
TCGA: ENSG00000164082
COSMIC: GRM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164082ENST00000296479H7BXL3
ENSG00000164082ENST00000395052Q14416
ENSG00000164082ENST00000419928C9JD41
ENSG00000164082ENST00000442933C9JL63

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
182970542008Identification of a serotonin/glutamate receptor complex implicated in psychosis.235
166789212006The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats.51
229881162012Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling.51
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
231297622012Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function.42
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
196354712009Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease.28
267582132016Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.23
249498662014Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics.22
199454952010Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression.21

Citation

Dessen P

GRM2 (glutamate metabotropic receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/55952/grm2