GRM3 (glutamate metabotropic receptor 3)

2012-01-01 Affiliation

Identity

HGNC

GRM3

LOCATION

7q21.11

LOCUSID

2913

ALIAS

GLUR3,GPRC1C,MGLUR3,mGlu3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2913
MIM: 601115
HGNC: 4595
Ensembl: ENSG00000198822

Variants:

dbSNP: 2913
ClinVar: 2913
TCGA: ENSG00000198822
COSMIC: GRM3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198822	ENST00000361669	Q14832
ENSG00000198822	ENST00000361669	A4D1D0
ENSG00000198822	ENST00000421579	C9JIT1
ENSG00000198822	ENST00000439827	Q14832
ENSG00000198822	ENST00000441140	C9JUH9
ENSG00000198822	ENST00000454217	C9J2I2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)	REACTOME	R-HSA-420499
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA444460	Heroin Dependence	Disease	ClinicalAnnotation, Literature, MultilinkAnnotation	associated		24498053
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated	PD	19451915, 25096017, 25209194
PA451257	risperidone	Chemical	ClinicalAnnotation	associated	PD	19451915
PA452233	antipsychotics	Chemical	ClinicalAnnotation	associated	PD	25096017, 25209194
PA452619	heroin	Chemical	ClinicalAnnotation	associated

References

Pubmed ID	Year	Title	Citations
18583979	2008	Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.	395
16380905	2005	Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.	131
15310849	2004	Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.	121
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
12786977	2003	Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins.	74
17636131	2007	Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function.	69
17636131	2007	Epistasis between catechol-O-methyltransferase and type II metabotropic glutamate receptor 3 genes on working memory brain function.	69
21946352	2011	Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.	67
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
18541626	2008	The group II metabotropic glutamate receptor 3 (mGluR3, mGlu3, GRM3): expression, function and involvement in schizophrenia.	59

Citation

Dessen P

GRM3 (glutamate metabotropic receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52514/grm3