GRM4 (glutamate metabotropic receptor 4)

2007-02-01  

Identity

HGNC
GRM4
LOCATION
6p21.31
LOCUSID
2914
ALIAS
GPRC1D,MGLUR4,mGlu4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2914
MIM: 604100
HGNC: 4596
Ensembl: ENSG00000124493

Variants:

dbSNP: 2914
ClinVar: 2914
TCGA: ENSG00000124493
COSMIC: GRM4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124493ENST00000374177Q14833
ENSG00000124493ENST00000374181B7ZLU9
ENSG00000124493ENST00000455714Q14833
ENSG00000124493ENST00000535756Q14833
ENSG00000124493ENST00000538487Q14833
ENSG00000124493ENST00000538487A1L4F9
ENSG00000124493ENST00000544773Q14833
ENSG00000124493ENST00000609222Q14833
ENSG00000124493ENST00000609278V9GYR3
ENSG00000124493ENST00000609443V9GYB0

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Taste transductionKEGGko04742
Neuroactive ligand-receptor interactionKEGGhsa04080
Taste transductionKEGGhsa04742
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163809052005Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.131
208265422011A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors.81
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
158672252005Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance.32
178846342007A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation.27
168997342006Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas.23
249251922014Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression.17
253421252015Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors.16

Citation

Dessen P

GRM4 (glutamate metabotropic receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46524/grm4