GRM7 (glutamate metabotropic receptor 7)

2014-11-01  

Identity

HGNC
LOCATION
3p26.1
LOCUSID
ALIAS
GLUR7,GPRC1G,MGLU7,MGLUR7,NEDSHBA,PPP1R87
FUSION GENES

Other Information

Locus ID:

NCBI: 2917
MIM: 604101
HGNC: 4599
Ensembl: ENSG00000196277

Variants:

dbSNP: 2917
ClinVar: 2917
TCGA: ENSG00000196277
COSMIC: GRM7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196277ENST00000357716Q14831
ENSG00000196277ENST00000389335Q14831
ENSG00000196277ENST00000389336Q14831
ENSG00000196277ENST00000402647A0A0A0MSC3
ENSG00000196277ENST00000435689F8WAW6
ENSG00000196277ENST00000440923H7C3K2
ENSG00000196277ENST00000443259F8WCR9
ENSG00000196277ENST00000445087C9JMT3
ENSG00000196277ENST00000448328C9JU97
ENSG00000196277ENST00000467425Q14831
ENSG00000196277ENST00000486284Q14831

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447197Attention Deficit Disorder with HyperactivityDiseaseVariantAnnotationnot associatedPD
PA450464methylphenidateChemicalVariantAnnotationnot associatedPD
PA451257risperidoneChemicalClinicalAnnotationassociatedPD26905411

References

Pubmed IDYearTitleCitations
197363512009Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation.151
200389472011Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.101
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
190471832009GRM7 variants confer susceptibility to age-related hearing impairment.63
190471832009GRM7 variants confer susceptibility to age-related hearing impairment.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
200685912010A genome-wide association study for age-related hearing impairment in the Saami.34

Citation

Dessen P

GRM7 (glutamate metabotropic receptor 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64053/grm7