GRM8 (glutamate metabotropic receptor 8)

2021-06-01  

Identity

HGNC
LOCATION
7q31.33
LOCUSID
ALIAS
GLUR8,GPRC1H,MGLUR8,mGlu8

Other Information

Locus ID:

NCBI: 2918
MIM: 601116
HGNC: 4600
Ensembl: ENSG00000179603

Variants:

dbSNP: 2918
ClinVar: 2918
TCGA: ENSG00000179603
COSMIC: GRM8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179603ENST00000339582O00222
ENSG00000179603ENST00000341617O00222
ENSG00000179603ENST00000358373O00222
ENSG00000179603ENST00000412160C9J7I1
ENSG00000179603ENST00000444921A0A0A0MT06
ENSG00000179603ENST00000457830E7ETK3
ENSG00000179603ENST00000465844H7C4V5
ENSG00000179603ENST00000472701O00222

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
192682762009Genome-wide association study of smoking initiation and current smoking.77
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
186185932009Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.42
186185932009Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence.42
176845442007Systematic association mapping identifies NELL1 as a novel IBD disease gene.38
181957152008Genotype patterns that contribute to increased risk for or protection from developing heroin addiction.37
203989082010Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.32

Citation

Dessen P

GRM8 (glutamate metabotropic receptor 8)

Atlas Genet Cytogenet Oncol Haematol. 2021-06-01

Online version: http://atlasgeneticsoncology.org/gene/58253/grm8